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    Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer

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    Author
    Nguyen, Nam P.; Ceizyk, Misty; Vos, Paul; Betz, Michael; Chi, Alexander; Almeida, Fabio; Davis, Rick; Slane, Benjamin; Gelumbauskas, Steven; Smith-Raymond, Lexie; Abraham, Dave; Stevie, Michelle; Jang, Siyoung; Vinh-Hung, Vincent
    Abstract
    The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatment toxicity and loco-regional control were assessed. At a median follow-up of 32 months (6-47 months), no patient developed loco-regional recurrence. Two patients (6%) developed distant metastases. Grade 3-4 acute toxicity was respectively 72% and 25% for mucositis and gastrointestinal toxicity. Two patients (6%) had long-term dependence on tube feedings. Dose-volume histogram demonstrated excellent target volume coverage and low radiation dose to the organs at risk for complications. IGRT provides excellent loco-regional control but acute toxicity remains significant and needs to be addressed in future prospective trials. The feasibility of Tomotherapy to decrease radiation dose to the normal tissues merits further investigations.
    URI
    http://hdl.handle.net/10342/7732
    Date
    2013-03-28
    Citation:
    APA:
    Nguyen, Nam P., & Ceizyk, Misty, & Vos, Paul, & Betz, Michael, & Chi, Alexander, & Almeida, Fabio, & Davis, Rick, & Slane, Benjamin, & Gelumbauskas, Steven, & Smith-Raymond, Lexie, & Abraham, Dave, & Stevie, Michelle, & Jang, Siyoung, & Vinh-Hung, Vincent. (March 2013). Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer. PLoS ONE, (8:3), p.1-6. Retrieved from http://hdl.handle.net/10342/7732

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    MLA:
    Nguyen, Nam P., and Ceizyk, Misty, and Vos, Paul, and Betz, Michael, and Chi, Alexander, and Almeida, Fabio, and Davis, Rick, and Slane, Benjamin, and Gelumbauskas, Steven, and Smith-Raymond, Lexie, and Abraham, Dave, and Stevie, Michelle, and Jang, Siyoung, and Vinh-Hung, Vincent. "Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer". PLoS ONE. 8:3. (1-6.), March 2013. March 03, 2021. http://hdl.handle.net/10342/7732.
    Chicago:
    Nguyen, Nam P. and Ceizyk, Misty and Vos, Paul and Betz, Michael and Chi, Alexander and Almeida, Fabio and Davis, Rick and Slane, Benjamin and Gelumbauskas, Steven and Smith-Raymond, Lexie and Abraham, Dave and Stevie, Michelle and Jang, Siyoung and Vinh-Hung, Vincent, "Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer," PLoS ONE 8, no. 3 (March 2013), http://hdl.handle.net/10342/7732 (accessed March 03, 2021).
    AMA:
    Nguyen, Nam P., Ceizyk, Misty, Vos, Paul, Betz, Michael, Chi, Alexander, Almeida, Fabio, Davis, Rick, Slane, Benjamin, Gelumbauskas, Steven, Smith-Raymond, Lexie, Abraham, Dave, Stevie, Michelle, Jang, Siyoung, Vinh-Hung, Vincent. Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer. PLoS ONE. March 2013; 8(3) 1-6. http://hdl.handle.net/10342/7732. Accessed March 03, 2021.
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