Is there a metabolic program in the skeletal muscle of obese individuals?
Author
Houmard, Joseph A.; Pories, Walter J.; Dohm, G. Lynis
Abstract
Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition.
Date
2011-04-26
Citation:
APA:
Houmard, Joseph A., & Pories, Walter J., & Dohm, G. Lynis. (April 2011).
Is there a metabolic program in the skeletal muscle of obese individuals?.
Journal of Obesity,
(2011:250496), p.1-11. Retrieved from
http://hdl.handle.net/10342/7745
MLA:
Houmard, Joseph A., and Pories, Walter J., and Dohm, G. Lynis.
"Is there a metabolic program in the skeletal muscle of obese individuals?". Journal of Obesity.
2011:250496. (1-11.),
April 2011.
April 19, 2021.
http://hdl.handle.net/10342/7745.
Chicago:
Houmard, Joseph A. and Pories, Walter J. and Dohm, G. Lynis,
"Is there a metabolic program in the skeletal muscle of obese individuals?," Journal of Obesity 2011, no.
250496 (April 2011),
http://hdl.handle.net/10342/7745 (accessed
April 19, 2021).
AMA:
Houmard, Joseph A., Pories, Walter J., Dohm, G. Lynis.
Is there a metabolic program in the skeletal muscle of obese individuals?. Journal of Obesity.
April 2011;
2011(250496)
1-11. http://hdl.handle.net/10342/7745. Accessed
April 19, 2021.
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