Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish
Author
Diotel, Nicolas; Servili, Arianna; Gueguen, Marie-Madeleine; Mironov, Svetlana; Pellegrini, Elisabeth; Vaillant, Colette; Zhu, Yong; Kah, Olivier; Anglade, Isabelle
Abstract
In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone and/or its metabolites could be involved in functions not related to reproduction, particularly in neurodevelopment. In this context, the adult fish brain is of particular interest, as it exhibits constant growth and high neurogenic activity that is supported by radial glia progenitors. However, although synthesis of neuroprogestagens has been documented recently in the brain of zebrafish, information on the presence of progesterone receptors is very limited. In zebrafish, a single nuclear progesterone receptor (pgr) has been cloned and characterized. Here, we demonstrate that this pgr is widely distributed in all regions of the zebrafish brain. Interestingly, we show that Pgr is strongly expressed in radial glial cells and more weakly in neurons. Finally, we present evidence, based on quantitative PCR and immunohistochemistry, that nuclear progesterone receptor mRNA and proteins are upregulated by estrogens in the brain of adult zebrafish. These data document for the first time the finding that radial glial cells are preferential targets for peripheral progestagens and/or neuroprogestagens. Given the crucial roles of radial glial cells in adult neurogenesis, the potential effects of progestagens on their activity and the fate of daughter cells require thorough investigation.
Date
2011-11-30
Citation:
APA:
Diotel, Nicolas, & Servili, Arianna, & Gueguen, Marie-Madeleine, & Mironov, Svetlana, & Pellegrini, Elisabeth, & Vaillant, Colette, & Zhu, Yong, & Kah, Olivier, & Anglade, Isabelle. (November 2011).
Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/7753
MLA:
Diotel, Nicolas, and Servili, Arianna, and Gueguen, Marie-Madeleine, and Mironov, Svetlana, and Pellegrini, Elisabeth, and Vaillant, Colette, and Zhu, Yong, and Kah, Olivier, and Anglade, Isabelle.
"Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish". .
. (),
November 2011.
September 25, 2023.
http://hdl.handle.net/10342/7753.
Chicago:
Diotel, Nicolas and Servili, Arianna and Gueguen, Marie-Madeleine and Mironov, Svetlana and Pellegrini, Elisabeth and Vaillant, Colette and Zhu, Yong and Kah, Olivier and Anglade, Isabelle,
"Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish," , no.
(November 2011),
http://hdl.handle.net/10342/7753 (accessed
September 25, 2023).
AMA:
Diotel, Nicolas, Servili, Arianna, Gueguen, Marie-Madeleine, Mironov, Svetlana, Pellegrini, Elisabeth, Vaillant, Colette, Zhu, Yong, Kah, Olivier, Anglade, Isabelle.
Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish. .
November 2011;
():
.
http://hdl.handle.net/10342/7753. Accessed
September 25, 2023.
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