A case of pulmonary hemorrhage and renal failure
Meara, Alexa S.; Harrington, Daphne M.; Foster, Jennifer; Vachharajani, Tushar J.; Desai, Tejas
Background: Alveolar hemorrhage can be seen in many vasculitic disorders. However, granulomatosis polyangiitis (formerly Wegener’s granulomatosis) uncommonly presents with life threatening alveolar hemorrhage and has only been discussed in a few case reports . Case Presentation: A 53 year old Caucasian male presented with hemoptysis and profound anemia. Two weeks prior, he had presented with abdominal pain with normal renal function and numerous pulmonary nodules. During the current admission, the patient was hypoxic with acute renal failure requiring hemodialysis. Urine sediment demonstrated dysmorphic red blood cells. A bronchoscopy revealed diffuse alveolar hemorrhage. The diagnosis of pulmonary-renal syndrome was made and therapeutic plasma exchange was initiated. Laboratory studies were significant for a c-ANCA titer positive at 1:640 FIU and anti-proteinase (PR)-3 antibody titer positive with 78.3 U/ml. Renal biopsy demonstrated necrotizing crescentic glomerulonephritis. A diagnosis of granulomatosis vasculitis was determined. Conclusion: Alveolar hemorrhage is rare to be the presenting symptom of granulomatosis vasculitis where the common presenting features are recurrent sinusitis, epistaxis, chronic otitis media or rhinitis. Physicians should consider granulomatosis vasculitis in the differential diagnosis of pulmonary-renal syndrome presenting with hemoptysis.
Meara, Alexa S., & Harrington, Daphne M., & Foster, Jennifer, & Vachharajani, Tushar J., & Desai, Tejas. (December 2012). A case of pulmonary hemorrhage and renal failure. The Open Urology & Nephrology Journal, (5:1), p.40-47. Retrieved from http://hdl.handle.net/10342/7762
Meara, Alexa S., and Harrington, Daphne M., and Foster, Jennifer, and Vachharajani, Tushar J., and Desai, Tejas. "A case of pulmonary hemorrhage and renal failure". The Open Urology & Nephrology Journal. 5:1. (40-47.), December 2012. November 26, 2022. http://hdl.handle.net/10342/7762.
Meara, Alexa S. and Harrington, Daphne M. and Foster, Jennifer and Vachharajani, Tushar J. and Desai, Tejas, "A case of pulmonary hemorrhage and renal failure," The Open Urology & Nephrology Journal 5, no. 1 (December 2012), http://hdl.handle.net/10342/7762 (accessed November 26, 2022).
Meara, Alexa S., Harrington, Daphne M., Foster, Jennifer, Vachharajani, Tushar J., Desai, Tejas. A case of pulmonary hemorrhage and renal failure. The Open Urology & Nephrology Journal. December 2012; 5(1) 40-47. http://hdl.handle.net/10342/7762. Accessed November 26, 2022.