• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling

    Thumbnail
    View/ Open
    journal.pone.0074550.PDF (750.8Kb)

    Show full item record
    
    Author
    Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C.
    Abstract
    Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk is central to the multiple aberrantly modulated molecules in SLE T cells. Using a gene expression array, we demonstrate that forced expression of Syk in normal T cells reproduces most of the aberrantly expressed molecules whereas silencing of Syk in SLE T cells normalizes the expression of most abnormally expressed molecules. Protein along with gene expression modulation for select molecules was confirmed. Specifically, levels of cytokine IL-21, cell surface receptor CD44, and intracellular molecules PP2A and OAS2 increased following Syk overexpression in normal T cells and decreased after Syk silencing in SLE T cells. Our results demonstrate that levels of Syk affect the expression of a number of enzymes, cytokines and receptors that play a key role in the development of disease pathogenesis in SLE and provide support for therapeutic targeting in SLE patients.
    URI
    http://hdl.handle.net/10342/7778
    Date
    2013-08-27
    Citation:
    APA:
    Grammatikos, Alexandros P., & Ghosh, Debjani, & Devlin, Amy, & Kyttaris, Vasileios C., & Tsokos, George C.. (August 2013). Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling. PLoS ONE, (8:8), p.1-9. Retrieved from http://hdl.handle.net/10342/7778

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Grammatikos, Alexandros P., and Ghosh, Debjani, and Devlin, Amy, and Kyttaris, Vasileios C., and Tsokos, George C.. "Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling". PLoS ONE. 8:8. (1-9.), August 2013. April 19, 2021. http://hdl.handle.net/10342/7778.
    Chicago:
    Grammatikos, Alexandros P. and Ghosh, Debjani and Devlin, Amy and Kyttaris, Vasileios C. and Tsokos, George C., "Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling," PLoS ONE 8, no. 8 (August 2013), http://hdl.handle.net/10342/7778 (accessed April 19, 2021).
    AMA:
    Grammatikos, Alexandros P., Ghosh, Debjani, Devlin, Amy, Kyttaris, Vasileios C., Tsokos, George C.. Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling. PLoS ONE. August 2013; 8(8) 1-9. http://hdl.handle.net/10342/7778. Accessed April 19, 2021.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback