• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience

    Thumbnail
    View/ Open
    PHY2-6-e13588.pdf (259.2Kb)

    Show full item record
    
    Author
    Chung, Susie; Rosenberry, Ryan; Ryan, Terence E.; Munson, Madison; Dombrowsky, Thomas; Park, Suwon; Nasirian, Aida; Haykowsky, Mark J.; Nelson, Michael D.
    Abstract
    Age is the greatest risk factor for chronic disease and is associated with a marked decline in functional capacity and quality of life. A key factor contributing to loss of function in older adults is the decline in skeletal muscle function. While the exact mechanism(s) remains incompletely understood, age-related mitochondrial dysfunction is thought to play a major role. To explore this question further, we studied 15 independently living seniors (age: 72 ± 5 years; m/f: 4/11; BMI: 27.6 ± 5.9) and 17 young volunteers (age: 25 ± 4 years; m/f: 8/9; BMI: 24.0 ± 3.3). Skeletal muscle oxidative function was measured in forearm muscle from the recovery kinetics of muscle oxygen consumption using near-infrared spectroscopy (NIRS). Muscle oxygen consumption was calculated as the slope of change in hemoglobin saturation during a series of rapid, supra-systolic arterial cuff occlusions following a brief bout of exercise. Aging was associated with a significant prolongation of the time constant of oxidative recovery following exercise (51.8 ± 5.4 sec vs. 37.1 ± 2.1 sec, P = 0.04, old vs. young, respectively). This finding suggests an overall reduction in mitochondrial function with age in nonlocomotor skeletal muscle. That these data were obtained using NIRS holds great promise in gerontology for quantitative assessment of skeletal muscle oxidative function at the bed side or clinic.
    URI
    http://hdl.handle.net/10342/7786
    Date
    2018-02
    Citation:
    APA:
    Chung, Susie, & Rosenberry, Ryan, & Ryan, Terence E., & Munson, Madison, & Dombrowsky, Thomas, & Park, Suwon, & Nasirian, Aida, & Haykowsky, Mark J., & Nelson, Michael D.. (February 2018). Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience. Physiological Reports, (6:3), p.. Retrieved from http://hdl.handle.net/10342/7786

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Chung, Susie, and Rosenberry, Ryan, and Ryan, Terence E., and Munson, Madison, and Dombrowsky, Thomas, and Park, Suwon, and Nasirian, Aida, and Haykowsky, Mark J., and Nelson, Michael D.. "Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience". Physiological Reports. 6:3. (.), February 2018. March 03, 2021. http://hdl.handle.net/10342/7786.
    Chicago:
    Chung, Susie and Rosenberry, Ryan and Ryan, Terence E. and Munson, Madison and Dombrowsky, Thomas and Park, Suwon and Nasirian, Aida and Haykowsky, Mark J. and Nelson, Michael D., "Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience," Physiological Reports 6, no. 3 (February 2018), http://hdl.handle.net/10342/7786 (accessed March 03, 2021).
    AMA:
    Chung, Susie, Rosenberry, Ryan, Ryan, Terence E., Munson, Madison, Dombrowsky, Thomas, Park, Suwon, Nasirian, Aida, Haykowsky, Mark J., Nelson, Michael D.. Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience. Physiological Reports. February 2018; 6(3) . http://hdl.handle.net/10342/7786. Accessed March 03, 2021.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback