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    Tolerogenic vaccines for multiple sclerosis

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    Author
    Mannie, Mark D.; Curtis, Alan D. II
    Abstract
    Tolerogenic vaccines represent a new class of vaccine designed to re-establish immunological tolerance, restore immune homeostasis, and thereby reverse autoimmune disease. Tolerogenic vaccines induce long-term, antigen-specific, inhibitory memory that blocks pathogenic T cell responses via loss of effector T cells and gain of regulatory T cell function. Substantial advances have been realized in the generation of tolerogenic vaccines that inhibit experimental autoimmune encephalomyelitis in a preclinical setting, and these vaccines may be a prequel of the tolerogenic vaccines that may have therapeutic benefit in Multiple Sclerosis. The purpose here is to provide a snapshot of the current concepts and future prospects of tolerogenic vaccination for Multiple Sclerosis, along with the central challenges to clinical application.
    URI
    http://hdl.handle.net/10342/7818
    Subject
    autoimmune disease, experimental autoimmune encephalomyelitis, immune, multiple sclerosis, myelin, neuroantigen, T lymphocytes, therapy, tolerance, vaccine
    Date
    2013-01-28
    Citation:
    APA:
    Mannie, Mark D., & Curtis, Alan D. II. (January 2013). Tolerogenic vaccines for multiple sclerosis. Hum Vaccin Immunother, (9:5), p.1032–1038. Retrieved from http://hdl.handle.net/10342/7818

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Mannie, Mark D., and Curtis, Alan D. II. "Tolerogenic vaccines for multiple sclerosis". Hum Vaccin Immunother. 9:5. (1032–1038.), January 2013. February 24, 2021. http://hdl.handle.net/10342/7818.
    Chicago:
    Mannie, Mark D. and Curtis, Alan D. II, "Tolerogenic vaccines for multiple sclerosis," Hum Vaccin Immunother 9, no. 5 (January 2013), http://hdl.handle.net/10342/7818 (accessed February 24, 2021).
    AMA:
    Mannie, Mark D., Curtis, Alan D. II. Tolerogenic vaccines for multiple sclerosis. Hum Vaccin Immunother. January 2013; 9(5) 1032–1038. http://hdl.handle.net/10342/7818. Accessed February 24, 2021.
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