• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell

    Thumbnail
    View/ Open
    pharmaceuticals-12-00124.pdf (6.517Mb)

    Show full item record
    
    Author
    Poma, Paola; Labbozzetta, Manuela; McCubrey, James A.; Ramarosandratana, Aro Vonjy; Sajeva, Maurizio; Zito, Pietro; Notarbartolo, Monica
    Abstract
    Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-κB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.
    URI
    http://hdl.handle.net/10342/7824
    Subject
    acute myeloid leukemia cell; Cyphostemma juttae; essential oil; Kalanchoe beharensis; multidrug resistance; NF-κB
    Date
    2019-08-26
    Citation:
    APA:
    Poma, Paola, & Labbozzetta, Manuela, & McCubrey, James A., & Ramarosandratana, Aro Vonjy, & Sajeva, Maurizio, & Zito, Pietro, & Notarbartolo, Monica. (August 2019). Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell. Pharmaceuticals, (124. Retrieved from http://hdl.handle.net/10342/7824

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Poma, Paola, and Labbozzetta, Manuela, and McCubrey, James A., and Ramarosandratana, Aro Vonjy, and Sajeva, Maurizio, and Zito, Pietro, and Notarbartolo, Monica. "Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell". Pharmaceuticals. . (124.), August 2019. March 01, 2021. http://hdl.handle.net/10342/7824.
    Chicago:
    Poma, Paola and Labbozzetta, Manuela and McCubrey, James A. and Ramarosandratana, Aro Vonjy and Sajeva, Maurizio and Zito, Pietro and Notarbartolo, Monica, "Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell," Pharmaceuticals 12, no. (August 2019), http://hdl.handle.net/10342/7824 (accessed March 01, 2021).
    AMA:
    Poma, Paola, Labbozzetta, Manuela, McCubrey, James A., Ramarosandratana, Aro Vonjy, Sajeva, Maurizio, Zito, Pietro, Notarbartolo, Monica. Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell. Pharmaceuticals. August 2019; 12() 124. http://hdl.handle.net/10342/7824. Accessed March 01, 2021.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback