The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

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Author
Krewson, Elizabeth A.; Sanderlin, Edward J.; Marie, Mona A.; Akhtar, Shayan Nik; Velcicky, Juraj; Loetscher, Pius; Yang, Li V.
Abstract
be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the Ga12/13/Rho GTPase signaling pathway. Evaluation of GPR4 in the inflammatoryresponse using the acute hindlimb ischemia-reperfusion mouse model revealed that GPR4 mediatestissue edema, inflammatory exudate formation, endothelial adhesion molecule expression, and leuko-cyte infiltration in the inflamed tissue. Genetic knockout and pharmacologic inhibition of GPR4alleviate tissue inflammation. These results suggest GPR4 is a pro-inflammatory receptor and couldbe targeted for therapeutic intervention.
URI
http://hdl.handle.net/10342/7827
Date
2020-02-21
Citation:
APA:
Krewson, Elizabeth A., & Sanderlin, Edward J., & Marie, Mona A., & Akhtar, Shayan Nik, & Velcicky, Juraj, & Loetscher, Pius, & Yang, Li V.. (February 2020). The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells. iScience, (23:2), p.. Retrieved from http://hdl.handle.net/10342/7827

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MLA:
Krewson, Elizabeth A., and Sanderlin, Edward J., and Marie, Mona A., and Akhtar, Shayan Nik, and Velcicky, Juraj, and Loetscher, Pius, and Yang, Li V.. "The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells". iScience. 23:2. (.), February 2020. November 25, 2020. http://hdl.handle.net/10342/7827.
Chicago:
Krewson, Elizabeth A. and Sanderlin, Edward J. and Marie, Mona A. and Akhtar, Shayan Nik and Velcicky, Juraj and Loetscher, Pius and Yang, Li V., "The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells," iScience 23, no. 2 (February 2020), http://hdl.handle.net/10342/7827 (accessed November 25, 2020).
AMA:
Krewson, Elizabeth A., Sanderlin, Edward J., Marie, Mona A., Akhtar, Shayan Nik, Velcicky, Juraj, Loetscher, Pius, Yang, Li V.. The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells. iScience. February 2020; 23(2) . http://hdl.handle.net/10342/7827. Accessed November 25, 2020.
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