• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice

    Thumbnail
    View/ Open
    1-s2.0-S2405844019303445-main.pdf (1.512Mb)

    Show full item record
    
    Author
    Rao, Zhijian; Landry, Taylor; Li, Peixin; Bunner, Wyatt; Laing, Brenton Thomas; Yuan, Yuan; Huang, Hu
    Abstract
    α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. However, the role of α-Klotho in the regulation of energy metabolism is complex and poorly understood. Here we investigated the effects of 5 weeks peripheral administration of α-Klotho in high fat diet induced obese mice. Food intake, blood glucose, and body weight were measured daily. Energy expenditure was determined with indirect calorimetry and body composition with magnetic resonance imaging. Liver and adipose tissue were collected for lipid content measurements and gene expression analysis. α-Klotho-treated mice experienced reduced adiposity, increased lean mass, and elevated energy expenditure, despite no changes in food intake, body weight, or fed blood glucose levels. Lipid accumulation in liver and adipose tissue was also reduced compared to controls. Furthermore, Real-time quantitative PCR showed reduced expression of key lipogenic genes in α-Klotho treated mice in these organs. Taken together, these data suggest encouraging therapeutic potential of α-Klotho and highlight a need for further research into the specific mechanisms explaining improved body composition, elevated energy expenditure, and reduced lipid content in both liver and adipose tissue in α-Klotho-treated mice.
    URI
    http://hdl.handle.net/10342/7840
    Subject
    Molecular biology, Physiology
    Date
    2019-04-05
    Citation:
    APA:
    Rao, Zhijian, & Landry, Taylor, & Li, Peixin, & Bunner, Wyatt, & Laing, Brenton Thomas, & Yuan, Yuan, & Huang, Hu. (April 2019). Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice. Heliyon, (. Retrieved from http://hdl.handle.net/10342/7840

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Rao, Zhijian, and Landry, Taylor, and Li, Peixin, and Bunner, Wyatt, and Laing, Brenton Thomas, and Yuan, Yuan, and Huang, Hu. "Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice". Heliyon. . (.), April 2019. August 10, 2022. http://hdl.handle.net/10342/7840.
    Chicago:
    Rao, Zhijian and Landry, Taylor and Li, Peixin and Bunner, Wyatt and Laing, Brenton Thomas and Yuan, Yuan and Huang, Hu, "Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice," Heliyon 5, no. (April 2019), http://hdl.handle.net/10342/7840 (accessed August 10, 2022).
    AMA:
    Rao, Zhijian, Landry, Taylor, Li, Peixin, Bunner, Wyatt, Laing, Brenton Thomas, Yuan, Yuan, Huang, Hu. Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice. Heliyon. April 2019; 5() . http://hdl.handle.net/10342/7840. Accessed August 10, 2022.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback