Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response

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Author
Salom, Emery; Penalver, Manuel; Homesley, Howard; Burrell, Matthew; Garrett, Audrey; Presant, Cary A; Rutledge, James; Chernick, Michael; Hallquist, Allan; Perree, Mathieu
Abstract
This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. A prospective, multi-institutional and blinded trial of the assay was conducted in 104 evaluable ovarian cancer patients treated with chemotherapy. The MiCK assay was performed prior to therapy, but treating physicians were not told of the results and selected treatment only on clinical criteria. Outcomes (response, time to relapse, and survival) were compared to the drug-induced apoptosis observed in the assay. The MiCK assay can predict the chemotherapy associated with better outcomes in ovarian cancer patients. This study quantifies outcome benefits on which a prospective randomized trial can be developed.
URI
http://hdl.handle.net/10342/7855
Date
2012-08-08
Citation:
APA:
Salom, Emery, & Penalver, Manuel, & Homesley, Howard, & Burrell, Matthew, & Garrett, Audrey, & Presant, Cary A, & Rutledge, James, & Chernick, Michael, & Hallquist, Allan, & Perree, Mathieu. (August 2012). Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response. Journal of Translational Medicine, (10:1), p.. Retrieved from http://hdl.handle.net/10342/7855

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MLA:
Salom, Emery, and Penalver, Manuel, and Homesley, Howard, and Burrell, Matthew, and Garrett, Audrey, and Presant, Cary A, and Rutledge, James, and Chernick, Michael, and Hallquist, Allan, and Perree, Mathieu. "Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response". Journal of Translational Medicine. 10:1. (.), August 2012. August 10, 2022. http://hdl.handle.net/10342/7855.
Chicago:
Salom, Emery and Penalver, Manuel and Homesley, Howard and Burrell, Matthew and Garrett, Audrey and Presant, Cary A and Rutledge, James and Chernick, Michael and Hallquist, Allan and Perree, Mathieu, "Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response," Journal of Translational Medicine 10, no. 1 (August 2012), http://hdl.handle.net/10342/7855 (accessed August 10, 2022).
AMA:
Salom, Emery, Penalver, Manuel, Homesley, Howard, Burrell, Matthew, Garrett, Audrey, Presant, Cary A, Rutledge, James, Chernick, Michael, Hallquist, Allan, Perree, Mathieu. Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response. Journal of Translational Medicine. August 2012; 10(1) . http://hdl.handle.net/10342/7855. Accessed August 10, 2022.
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