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    Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture

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    Author
    Fair, Patricia A.; Stavros, Hui-Chen; Mollenhauer, Meagan A.M.; DeWitt, Jamie C.; Henry, Natasha; Kannan, Kurunthachalam; Yun, Se Hun; Bossart, Gregory D.; Keil, Deborah E.; Peden-Adams, Margie M.
    Abstract
    Polybrominated diphenyl ethers (PBDEs) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. Toxicity of these compounds has become a concern because detectable levels of PBDEs are present in humans and wildlife and they are structurally similar to polychlorinated biphenyls (PCBs). This study examined the effects of the commercial penta-BDE mixture, DE-71, in adult female B6C3F1 mice on hematology, serum clinical chemistry, thyroid hormones, tissue histology, and several immunotoxicity end-points (lymphocyte proliferation, NK cell activity, splenic immunophenotypes, and SRBC-specific-IgM production). Mice were exposed via oral gavage for 28 days to achieve total administered doses (TAD) of 0, 0.5, 5, 50, or 100 mg/kg. No changes in histology, clinical chemistry, body or organ weights were observed. Serum total T3 and T4 levels were not altered by any of the DE-71 treatments. Peripheral blood monocyte numbers were decreased by the 0.5, 5, and 50 mg/kg treatments, but not by the 100 mg/kg TAD concentration. Compared to controls, mitogen-stimulated T- and B-cell proliferation was increased by the 100 mg/kg TAD concentration (ED50 = 60 mg/kg TAD [2.14 mg/kg/day] and 58 mg/kg TAD [2.57 mg/kg/day], respectively). NK cell activity was decreased compared to controls by the 100 mg/kg TAD concentration (ED50 = 20 mg/kg TAD [0.7 mg/kg/day]). No alterations were noted in thymic T-cell populations or in SRBC-specific-IgM production. Numbers of CD19+CD21−, CD19+CD21+, CD4+CD8−, CD4−CD8+, CD4−CD8−, and MHC-II+ cells in the spleen were not affected. However, the numbers of splenic CD4+CD8+ cells were decreased compared to the controls by 0.5, 5, and 100 mg/kg TAD. This study provides an assessment of the systemic toxicity and immunotoxicity of DE-71, and indicates that immune parameters are modulated at exposure concentrations lower than previously reported.
    URI
    http://hdl.handle.net/10342/7861
    Subject
    Polybrominated diphenyl ether, PBDE, DE-71, immune, hematology, splenic CD4+/CD8+ cells, serum clinical chemistry, thyroid hormone, histology
    Date
    2012-01-04
    Citation:
    APA:
    Fair, Patricia A., & Stavros, Hui-Chen, & Mollenhauer, Meagan A.M., & DeWitt, Jamie C., & Henry, Natasha, & Kannan, Kurunthachalam, & Yun, Se Hun, & Bossart, Gregory D., & Keil, Deborah E., & Peden-Adams, Margie M.. (January 2012). Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. , (), - . Retrieved from http://hdl.handle.net/10342/7861

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Fair, Patricia A., and Stavros, Hui-Chen, and Mollenhauer, Meagan A.M., and DeWitt, Jamie C., and Henry, Natasha, and Kannan, Kurunthachalam, and Yun, Se Hun, and Bossart, Gregory D., and Keil, Deborah E., and Peden-Adams, Margie M.. "Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture". . . (), January 2012. October 03, 2023. http://hdl.handle.net/10342/7861.
    Chicago:
    Fair, Patricia A. and Stavros, Hui-Chen and Mollenhauer, Meagan A.M. and DeWitt, Jamie C. and Henry, Natasha and Kannan, Kurunthachalam and Yun, Se Hun and Bossart, Gregory D. and Keil, Deborah E. and Peden-Adams, Margie M., "Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture," , no. (January 2012), http://hdl.handle.net/10342/7861 (accessed October 03, 2023).
    AMA:
    Fair, Patricia A., Stavros, Hui-Chen, Mollenhauer, Meagan A.M., DeWitt, Jamie C., Henry, Natasha, Kannan, Kurunthachalam, Yun, Se Hun, Bossart, Gregory D., Keil, Deborah E., Peden-Adams, Margie M.. Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. . January 2012; (): . http://hdl.handle.net/10342/7861. Accessed October 03, 2023.
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