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    Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study

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    Author
    Urbina, Elaine M.; Isom, Scott; Bell, Ronny A.; Bowlby, Deborah A.; D'Agostino Jr, Ralph; Daniels, Stephen R.; Dolan, Lawrence M.; Imperatore, Giuseppina; Marcovina, Santica M.; Merchant, Anwar T.; Reynolds, Kristi; Shah, Amy S.; Wadwa, R. Paul; Dabelea, Dana
    Abstract
    Background: The incidence of type 1 diabetes mellitus (T1DM) in children is increasing, resulting in higher burden of cardiovascular diseases due to diabetes mellitus–related vascular dysfunction. Methods and Results: We examined cardiovascular risk factors (CVRFs) and arterial parameters in 1809 youth with T1DM. Demographics, anthropometrics, blood pressure, and laboratory data were collected at T1DM onset and 5 years later. Pulse wave velocity and augmentation index were collected with tonometry. ANOVA or chi‐square tests were used to test for differences in measures of arterial parameters by CVRF. Area under the curve of CVRFs was entered in general linear models to explore determinants of accelerate vascular aging. Participants at the time of arterial measurement were 17.6±4.5 years old, 50% female, 76% non‐Hispanic white, and duration of T1DM was 7.8±1.9 years. Glycemic control was poor (glycated hemoglobin, 9.1±1.8%). All arterial parameters were higher in participants with glycated hemoglobin ≥9% and pulse wave velocity was higher with lower insulin sensitivity or longer duration of diabetes mellitus. Differences in arterial parameters were found by sex, age, and presence of obesity, hypertension, or dyslipidemia. In multivariable models, higher glycated hemoglobin, lower insulin sensitivity, body mass index, blood pressure, and lipid areas under the curve were associated with accelerated vascular aging. Conclusions: In young people with T1DM, persistent poor glycemic control and higher levels of traditional CVRFs are independently associated with arterial aging. Improving glycemic control and interventions to lower CVRFs may prevent future cardiovascular events in young individuals with T1DM.
    URI
    http://hdl.handle.net/10342/7882
    Subject
    arterial compliance; diabetes mellitus; pediatric; risk factor
    Date
    2019-07-02
    Citation:
    APA:
    Urbina, Elaine M., & Isom, Scott, & Bell, Ronny A., & Bowlby, Deborah A., & D'Agostino Jr, Ralph, & Daniels, Stephen R., & Dolan, Lawrence M., & Imperatore, Giuseppina, & Marcovina, Santica M., & Merchant, Anwar T., & Reynolds, Kristi, & Shah, Amy S., & Wadwa, R. Paul, & Dabelea, Dana. (July 2019). Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study. Journal of the American Heart Association, (8:13), p.. Retrieved from http://hdl.handle.net/10342/7882

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    MLA:
    Urbina, Elaine M., and Isom, Scott, and Bell, Ronny A., and Bowlby, Deborah A., and D'Agostino Jr, Ralph, and Daniels, Stephen R., and Dolan, Lawrence M., and Imperatore, Giuseppina, and Marcovina, Santica M., and Merchant, Anwar T., and Reynolds, Kristi, and Shah, Amy S., and Wadwa, R. Paul, and Dabelea, Dana. "Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study". Journal of the American Heart Association. 8:13. (.), July 2019. February 24, 2021. http://hdl.handle.net/10342/7882.
    Chicago:
    Urbina, Elaine M. and Isom, Scott and Bell, Ronny A. and Bowlby, Deborah A. and D'Agostino Jr, Ralph and Daniels, Stephen R. and Dolan, Lawrence M. and Imperatore, Giuseppina and Marcovina, Santica M. and Merchant, Anwar T. and Reynolds, Kristi and Shah, Amy S. and Wadwa, R. Paul and Dabelea, Dana, "Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study," Journal of the American Heart Association 8, no. 13 (July 2019), http://hdl.handle.net/10342/7882 (accessed February 24, 2021).
    AMA:
    Urbina, Elaine M., Isom, Scott, Bell, Ronny A., Bowlby, Deborah A., D'Agostino Jr, Ralph, Daniels, Stephen R., Dolan, Lawrence M., Imperatore, Giuseppina, Marcovina, Santica M., Merchant, Anwar T., Reynolds, Kristi, Shah, Amy S., Wadwa, R. Paul, Dabelea, Dana. Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study. Journal of the American Heart Association. July 2019; 8(13) . http://hdl.handle.net/10342/7882. Accessed February 24, 2021.
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