Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids
Author
Anderson, Ethan; Taylor, David A.
Abstract
Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in implementing them as a reliable and consistent drug therapy. The foremost of these is that a molecular mechanism and relevant dosages have not been firmly established in other forms of cardiovascular disease. In this brief review, we highlight the current state of knowledge regarding the mechanisms behind n-3 PUFA action in the cardiovascular system. We also propose the novel hypothesis that lipid peroxidation products derived from n-3 PUFAs may be driving much of their beneficial cardiovascular effects, particularly in the myocardium. We conclude by discussing evidence to support this hypothesis, and its possible clinical ramifications.
Date
2012-07-02
Citation:
APA:
Anderson, Ethan, & Taylor, David A.. (July 2012).
Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/7901
MLA:
Anderson, Ethan, and Taylor, David A..
"Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids". .
. (),
July 2012.
September 27, 2023.
http://hdl.handle.net/10342/7901.
Chicago:
Anderson, Ethan and Taylor, David A.,
"Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids," , no.
(July 2012),
http://hdl.handle.net/10342/7901 (accessed
September 27, 2023).
AMA:
Anderson, Ethan, Taylor, David A..
Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids. .
July 2012;
():
.
http://hdl.handle.net/10342/7901. Accessed
September 27, 2023.
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