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    Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids

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    Author
    Anderson, Ethan J.; Taylor, David A.
    Abstract
    Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in implementing them as a reliable and consistent drug therapy. The foremost of these is that a molecular mechanism and relevant dosages have not been firmly established in other forms of cardiovascular disease. In this brief review, we highlight the current state of knowledge regarding the mechanisms behind n-3 PUFA action in the cardiovascular system. We also propose the novel hypothesis that lipid peroxidation products derived from n-3 PUFAs may be driving much of their beneficial cardiovascular effects, particularly in the myocardium. We conclude by discussing evidence to support this hypothesis, and its possible clinical ramifications.
    URI
    http://hdl.handle.net/10342/7901
    Date
    2012-07-02
    Citation:
    APA:
    Anderson, Ethan J., & Taylor, David A.. (July 2012). Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids. F1000 Medicine Reports, (4:13), p.1-8. Retrieved from http://hdl.handle.net/10342/7901

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    MLA:
    Anderson, Ethan J., and Taylor, David A.. "Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids". F1000 Medicine Reports. 4:13. (1-8.), July 2012. March 02, 2021. http://hdl.handle.net/10342/7901.
    Chicago:
    Anderson, Ethan J. and Taylor, David A., "Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids," F1000 Medicine Reports 4, no. 13 (July 2012), http://hdl.handle.net/10342/7901 (accessed March 02, 2021).
    AMA:
    Anderson, Ethan J., Taylor, David A.. Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids. F1000 Medicine Reports. July 2012; 4(13) 1-8. http://hdl.handle.net/10342/7901. Accessed March 02, 2021.
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