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    Stem cell models of human synapse development and degeneration

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    Author
    Wilson, Emily S.; Newell-Litwa, Karen
    Abstract
    Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain organoids from human-induced pluripotent stem cells (hIPSC). These hIPSC-derived brain models develop both excitatory and inhibitory synapses and functional synaptic activity. In this review, we address the ability of hIPSC-derived brain models to recapitulate synapse development and insights gained into the molecular mechanisms underlying synaptic alterations in neuronal disorders. We also discuss the potential for more accurate human brain models to advance our understanding of synapse development, degeneration, and therapeutic responses.
    URI
    http://hdl.handle.net/10342/7922
    Date
    2018-11-26
    Citation:
    APA:
    Wilson, Emily S., & Newell-Litwa, Karen. (November 2018). Stem cell models of human synapse development and degeneration. , (), - . Retrieved from http://hdl.handle.net/10342/7922

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    MLA:
    Wilson, Emily S., and Newell-Litwa, Karen. "Stem cell models of human synapse development and degeneration". . . (), November 2018. September 26, 2023. http://hdl.handle.net/10342/7922.
    Chicago:
    Wilson, Emily S. and Newell-Litwa, Karen, "Stem cell models of human synapse development and degeneration," , no. (November 2018), http://hdl.handle.net/10342/7922 (accessed September 26, 2023).
    AMA:
    Wilson, Emily S., Newell-Litwa, Karen. Stem cell models of human synapse development and degeneration. . November 2018; (): . http://hdl.handle.net/10342/7922. Accessed September 26, 2023.
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