Stem cell models of human synapse development and degeneration
Date
This item will be available on:
Authors
Wilson, Emily S.
Newell-Litwa, Karen
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain organoids from human-induced pluripotent stem cells (hIPSC). These hIPSC-derived brain models develop both excitatory and inhibitory synapses and functional synaptic activity. In this review, we address the ability of hIPSC-derived brain models to recapitulate synapse development and insights gained into the molecular mechanisms underlying synaptic alterations in neuronal disorders. We also discuss the potential for more accurate human brain models to advance our understanding of synapse development, degeneration, and therapeutic responses.
Description
Keywords
Citation
item.page.doi
10.1091/mbc.E18-04-0222