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    Single-institution comparative study on the outcomes of salvage cryotherapy versus salvage robotic prostatectomy for radio-resistant prostate cancer

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    Author
    Vora, Anup; Agarwal, Vidhi; Singh, Prabhjot; Patel, Rupen; Rivas, Rodolfo; Nething, Josh; Muruve, Nic
    Abstract
    Background Although primary treatment of localized prostate cancer provides excellent oncologic control, some men who chose radiotherapy experience a recurrence of disease. There is no consensus on the most appropriate management of these patients after radiotherapy failure. In this single-institution review, we compare our oncologic outcome and toxicity between salvage prostatectomy and cryotherapy treatments. Methods From January 2004 to June 2013, a total of 23 salvage procedures were performed. Six of those patients underwent salvage prostatectomy while 17 underwent salvage cryotherapy by two high-volume fellowship-trained urologists. Patients being considered for salvage therapy had localized disease at presentation, a prostate-specific antigen (PSA) < 10 ng/mL at recurrence, life expectancy > 10 years at recurrence, and a negative metastatic workup. Patients were followed to observe cancer progression and toxicity of treatment. Results Patients who underwent salvage cryotherapy were statistically older with a higher incidence of hypertension than our salvage prostatectomy cohort. With a mean follow up of 14.1 months and 7.2 months, the incidence of disease progression was 23.5% and 16.7% after salvage cryotherapy and prostatectomy, respectively. The overall complication rate was also 23.5% versus 16.7%, with the most frequent complication after salvage cryotherapy being urethral stricture and after salvage prostatectomy being severe urinary incontinence. There were no rectal injuries with salvage prostatectomy and one rectourethral fistula in the cohort after salvage cryotherapy. Conclusion While recurrences from primary radiotherapy for prostate cancer do occur, there is no consensus on its management. In our experience, salvage procedures were generally safe and effective. Both salvage cryotherapy and salvage prostatectomy allow for adequate cancer control with minimal toxicity.
    URI
    http://hdl.handle.net/10342/7946
    Subject
    Cryotherapy, Prostate cancer, Radioresistant, Robotic prostatectomy, Salvage
    Date
    2015
    Citation:
    APA:
    Vora, Anup, & Agarwal, Vidhi, & Singh, Prabhjot, & Patel, Rupen, & Rivas, Rodolfo, & Nething, Josh, & Muruve, Nic. (January 2015). Single-institution comparative study on the outcomes of salvage cryotherapy versus salvage robotic prostatectomy for radio-resistant prostate cancer. Prostate International, (4:1), p.. Retrieved from http://hdl.handle.net/10342/7946

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Vora, Anup, and Agarwal, Vidhi, and Singh, Prabhjot, and Patel, Rupen, and Rivas, Rodolfo, and Nething, Josh, and Muruve, Nic. "Single-institution comparative study on the outcomes of salvage cryotherapy versus salvage robotic prostatectomy for radio-resistant prostate cancer". Prostate International. 4:1. (.), January 2015. July 06, 2022. http://hdl.handle.net/10342/7946.
    Chicago:
    Vora, Anup and Agarwal, Vidhi and Singh, Prabhjot and Patel, Rupen and Rivas, Rodolfo and Nething, Josh and Muruve, Nic, "Single-institution comparative study on the outcomes of salvage cryotherapy versus salvage robotic prostatectomy for radio-resistant prostate cancer," Prostate International 4, no. 1 (January 2015), http://hdl.handle.net/10342/7946 (accessed July 06, 2022).
    AMA:
    Vora, Anup, Agarwal, Vidhi, Singh, Prabhjot, Patel, Rupen, Rivas, Rodolfo, Nething, Josh, Muruve, Nic. Single-institution comparative study on the outcomes of salvage cryotherapy versus salvage robotic prostatectomy for radio-resistant prostate cancer. Prostate International. January 2015; 4(1) . http://hdl.handle.net/10342/7946. Accessed July 06, 2022.
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