The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
Author
Myers, Valerie D.; McClung, Joseph M.; Wang, JuFang; Tahrir, Farzaneh G.; Gupta, Manish K.; Gordon, Jennifer; Kontos, Christopher H.; Khalili, Kamel; Cheung, Joseph Y.; Feldman, Arthur M.
Abstract
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy; binds to B-cell lymphoma 2, resulting in inhibition of apoptosis; attaches actin to the Z disk, providing structural support for the sarcomere; and links the α-adrenergic receptor with the L-type Ca2+ channel. When BAG3 is overexpressed in cancer cells, it facilitates prosurvival pathways that lead to insensitivity to chemotherapy, metastasis, cell migration, and invasiveness. In contrast, in the heart, mutations in BAG3 have been associated with a variety of phenotypes, including both hypertrophic/restrictive and dilated cardiomyopathy. In murine skeletal muscle and vasculature, a mutation in BAG3 leads to critical limb ischemia after femoral artery ligation. An understanding of the biology of BAG3 is relevant because it may provide a therapeutic target in patients with both cardiac and skeletal muscle disease.
Date
2018-02-26
Citation:
APA:
Myers, Valerie D., & McClung, Joseph M., & Wang, JuFang, & Tahrir, Farzaneh G., & Gupta, Manish K., & Gordon, Jennifer, & Kontos, Christopher H., & Khalili, Kamel, & Cheung, Joseph Y., & Feldman, Arthur M.. (February 2018).
The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/7994
MLA:
Myers, Valerie D., and McClung, Joseph M., and Wang, JuFang, and Tahrir, Farzaneh G., and Gupta, Manish K., and Gordon, Jennifer, and Kontos, Christopher H., and Khalili, Kamel, and Cheung, Joseph Y., and Feldman, Arthur M..
"The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease". .
. (),
February 2018.
November 30, 2023.
http://hdl.handle.net/10342/7994.
Chicago:
Myers, Valerie D. and McClung, Joseph M. and Wang, JuFang and Tahrir, Farzaneh G. and Gupta, Manish K. and Gordon, Jennifer and Kontos, Christopher H. and Khalili, Kamel and Cheung, Joseph Y. and Feldman, Arthur M.,
"The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease," , no.
(February 2018),
http://hdl.handle.net/10342/7994 (accessed
November 30, 2023).
AMA:
Myers, Valerie D., McClung, Joseph M., Wang, JuFang, Tahrir, Farzaneh G., Gupta, Manish K., Gordon, Jennifer, Kontos, Christopher H., Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M..
The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease. .
February 2018;
():
.
http://hdl.handle.net/10342/7994. Accessed
November 30, 2023.
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