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    Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome

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    Author
    Seridi, Loqmane; Leo, Gregory C.; Dohm, G. Lynis; Pories, Walter J.; Lenhard, James
    Abstract
    Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 dia- betes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabet- ics) that underwent RYGB surgery and seven lean subjects. Plasma samples from the obese patients were collected before the surgery and one week and three months after the surgery. We analyzed the metabolome in association to five hormones (Adiponectin, Insulin, Ghrelin, Leptin, and Resistin), four peptide hormones (GIP, Glucagon, GLP1, and PYY), and two cytokines (IL-6 and TNF). PCA showed samples cluster by surgery time and many microbially driven metabolites (indoles in particular) correlated with the three months after the surgery. Network analysis of metabolites revealed a connection between carbohydrate (mannosamine and glucosamine) and glyoxylate and confirms glyoxylate association to dia- betes. Only leptin and IL-6 had a significant association with the measured metabolites. Lep- tin decreased immediately after RYGB (before significant weight loss), whereas IL-6 showed no consistent response to RYGB. Moreover, leptin associated with tryptophan in support of the possible role of leptin in the regulation of serotonin synthesis pathways in the gut. These results suggest a potential link between gastric leptin and microbial-derived metabolites in the context of obesity and diabetes.
    URI
    http://hdl.handle.net/10342/8002
    Date
    2018-05-31
    Citation:
    APA:
    Seridi, Loqmane, & Leo, Gregory C., & Dohm, G. Lynis, & Pories, Walter J., & Lenhard, James. (May 2018). Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome. PLOS ONE, (13:5), p.. Retrieved from http://hdl.handle.net/10342/8002

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Seridi, Loqmane, and Leo, Gregory C., and Dohm, G. Lynis, and Pories, Walter J., and Lenhard, James. "Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome". PLOS ONE. 13:5. (.), May 2018. March 06, 2021. http://hdl.handle.net/10342/8002.
    Chicago:
    Seridi, Loqmane and Leo, Gregory C. and Dohm, G. Lynis and Pories, Walter J. and Lenhard, James, "Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome," PLOS ONE 13, no. 5 (May 2018), http://hdl.handle.net/10342/8002 (accessed March 06, 2021).
    AMA:
    Seridi, Loqmane, Leo, Gregory C., Dohm, G. Lynis, Pories, Walter J., Lenhard, James. Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome. PLOS ONE. May 2018; 13(5) . http://hdl.handle.net/10342/8002. Accessed March 06, 2021.
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