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    The Role of Retinoic Acid (RA) in Spermatogonial Differentiation

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    Author
    Busada, Jonathan T.; Geyer, Christopher B.
    Abstract
    Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the generation of functional spermatozoa. These processes are functionally and temporally decoupled, as they occur in distinct cell types that arise over a week apart, both in the neonatal and adult testis. However, our understanding is limited in terms of what cellular and molecular changes occur downstream of RA exposure that prepare differentiating spermatogonia for meiotic initiation. In this review, we describe the process of spermatogonial differentiation and summarize the current state of knowledge regarding RA signaling in spermatogonia.
    URI
    http://hdl.handle.net/10342/8016
    Subject
    developmental biology, differentiation, gonocyte, prospermatogonia, retinoic acid, retinoids, spermatogenesis, spermatogonia, testis
    Date
    2016
    Citation:
    APA:
    Busada, Jonathan T., & Geyer, Christopher B.. (January 2016). The Role of Retinoic Acid (RA) in Spermatogonial Differentiation. Biology of Reproduction, (. Retrieved from http://hdl.handle.net/10342/8016

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    MLA:
    Busada, Jonathan T., and Geyer, Christopher B.. "The Role of Retinoic Acid (RA) in Spermatogonial Differentiation". Biology of Reproduction. . (.), January 2016. March 03, 2021. http://hdl.handle.net/10342/8016.
    Chicago:
    Busada, Jonathan T. and Geyer, Christopher B., "The Role of Retinoic Acid (RA) in Spermatogonial Differentiation," Biology of Reproduction 94, no. (January 2016), http://hdl.handle.net/10342/8016 (accessed March 03, 2021).
    AMA:
    Busada, Jonathan T., Geyer, Christopher B.. The Role of Retinoic Acid (RA) in Spermatogonial Differentiation. Biology of Reproduction. January 2016; 94() . http://hdl.handle.net/10342/8016. Accessed March 03, 2021.
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