Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
Author
Hanley, Patrick; Sutter, Jennifer A.; Goodman, Noah G.; Du, Yangzhu; Sekiguchi, Debora R.; Meng, Wenzhao; Rickels, Michael R.; Naji, Ali; Luning Prak, Eline T.
Abstract
Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naïve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients.
Date
2017-10
Citation:
APA:
Hanley, Patrick, & Sutter, Jennifer A., & Goodman, Noah G., & Du, Yangzhu, & Sekiguchi, Debora R., & Meng, Wenzhao, & Rickels, Michael R., & Naji, Ali, & Luning Prak, Eline T.. (October 2017).
Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8037
MLA:
Hanley, Patrick, and Sutter, Jennifer A., and Goodman, Noah G., and Du, Yangzhu, and Sekiguchi, Debora R., and Meng, Wenzhao, and Rickels, Michael R., and Naji, Ali, and Luning Prak, Eline T..
"Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes". .
. (),
October 2017.
September 26, 2023.
http://hdl.handle.net/10342/8037.
Chicago:
Hanley, Patrick and Sutter, Jennifer A. and Goodman, Noah G. and Du, Yangzhu and Sekiguchi, Debora R. and Meng, Wenzhao and Rickels, Michael R. and Naji, Ali and Luning Prak, Eline T.,
"Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes," , no.
(October 2017),
http://hdl.handle.net/10342/8037 (accessed
September 26, 2023).
AMA:
Hanley, Patrick, Sutter, Jennifer A., Goodman, Noah G., Du, Yangzhu, Sekiguchi, Debora R., Meng, Wenzhao, Rickels, Michael R., Naji, Ali, Luning Prak, Eline T..
Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. .
October 2017;
():
.
http://hdl.handle.net/10342/8037. Accessed
September 26, 2023.
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