• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes

    Thumbnail
    View/ Open
    1-s2.0-S1521661617304175-main-2.pdf (965.9Kb)

    Show full item record
    
    Author
    Hanley, Patrick; Sutter, Jennifer A.; Goodman, Noah G.; Du, Yangzhu; Sekiguchi, Debora R.; Meng, Wenzhao; Rickels, Michael R.; Naji, Ali; Luning Prak, Eline T.
    Abstract
    Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naïve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients.
    URI
    http://hdl.handle.net/10342/8037
    Date
    2017-10
    Citation:
    APA:
    Hanley, Patrick, & Sutter, Jennifer A., & Goodman, Noah G., & Du, Yangzhu, & Sekiguchi, Debora R., & Meng, Wenzhao, & Rickels, Michael R., & Naji, Ali, & Luning Prak, Eline T.. (October 2017). Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. Clinical Immunology, (336-343. Retrieved from http://hdl.handle.net/10342/8037

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Hanley, Patrick, and Sutter, Jennifer A., and Goodman, Noah G., and Du, Yangzhu, and Sekiguchi, Debora R., and Meng, Wenzhao, and Rickels, Michael R., and Naji, Ali, and Luning Prak, Eline T.. "Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes". Clinical Immunology. . (336-343.), October 2017. August 11, 2022. http://hdl.handle.net/10342/8037.
    Chicago:
    Hanley, Patrick and Sutter, Jennifer A. and Goodman, Noah G. and Du, Yangzhu and Sekiguchi, Debora R. and Meng, Wenzhao and Rickels, Michael R. and Naji, Ali and Luning Prak, Eline T., "Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes," Clinical Immunology 183, no. (October 2017), http://hdl.handle.net/10342/8037 (accessed August 11, 2022).
    AMA:
    Hanley, Patrick, Sutter, Jennifer A., Goodman, Noah G., Du, Yangzhu, Sekiguchi, Debora R., Meng, Wenzhao, Rickels, Michael R., Naji, Ali, Luning Prak, Eline T.. Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes. Clinical Immunology. October 2017; 183() 336-343. http://hdl.handle.net/10342/8037. Accessed August 11, 2022.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback