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    Estrogen Regulates the Satellite Cell Compartment in Females

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    Author
    Collins, Brittany C.; Arpke, Robert W.; Larson, Alexie A.; Baumann, Cory W.; Xie, Ning; Cabelka, Christine A.; Nash, Nardina L.; Juppi, Hanna-Kaarina; Laakkonen, Eija K.; Sipilä, Sarianna; Kovanen, Vuokko; Spangenburg, Espen E.; Kyba, Michael; Lowe, Dawn A.
    Abstract
    Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.
    URI
    http://hdl.handle.net/10342/8082
    Date
    2019-07-09
    Citation:
    APA:
    Collins, Brittany C., & Arpke, Robert W., & Larson, Alexie A., & Baumann, Cory W., & Xie, Ning, & Cabelka, Christine A., & Nash, Nardina L., & Juppi, Hanna-Kaarina, & Laakkonen, Eija K., & Sipilä, Sarianna, & Kovanen, Vuokko, & Spangenburg, Espen E., & Kyba, Michael, & Lowe, Dawn A.. (July 2019). Estrogen Regulates the Satellite Cell Compartment in Females. Cell Reports, (368–381. Retrieved from http://hdl.handle.net/10342/8082

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    MLA:
    Collins, Brittany C., and Arpke, Robert W., and Larson, Alexie A., and Baumann, Cory W., and Xie, Ning, and Cabelka, Christine A., and Nash, Nardina L., and Juppi, Hanna-Kaarina, and Laakkonen, Eija K., and Sipilä, Sarianna, and Kovanen, Vuokko, and Spangenburg, Espen E., and Kyba, Michael, and Lowe, Dawn A.. "Estrogen Regulates the Satellite Cell Compartment in Females". Cell Reports. . (368–381.), July 2019. February 24, 2021. http://hdl.handle.net/10342/8082.
    Chicago:
    Collins, Brittany C. and Arpke, Robert W. and Larson, Alexie A. and Baumann, Cory W. and Xie, Ning and Cabelka, Christine A. and Nash, Nardina L. and Juppi, Hanna-Kaarina and Laakkonen, Eija K. and Sipilä, Sarianna and Kovanen, Vuokko and Spangenburg, Espen E. and Kyba, Michael and Lowe, Dawn A., "Estrogen Regulates the Satellite Cell Compartment in Females," Cell Reports 28, no. (July 2019), http://hdl.handle.net/10342/8082 (accessed February 24, 2021).
    AMA:
    Collins, Brittany C., Arpke, Robert W., Larson, Alexie A., Baumann, Cory W., Xie, Ning, Cabelka, Christine A., Nash, Nardina L., Juppi, Hanna-Kaarina, Laakkonen, Eija K., Sipilä, Sarianna, Kovanen, Vuokko, Spangenburg, Espen E., Kyba, Michael, Lowe, Dawn A.. Estrogen Regulates the Satellite Cell Compartment in Females. Cell Reports. July 2019; 28() 368–381. http://hdl.handle.net/10342/8082. Accessed February 24, 2021.
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