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    HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I

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    Author
    Rushing, Amanda W; Rushing, Blake; Hoang, Kimson; Sanders, Stephanie V; Péloponèse, Jean-Marie; Polakowski, Nicholas; Lemasson, Isabelle
    Abstract
    Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are no effective treatments to cure ATL, and ATL cells often acquire resistance to conventional chemotherapeutic agents. Accumulating evidence shows that development and maintenance of ATL requires key contributions from the viral protein, HTLV-1 basic leucine zipper factor (HBZ). In this study we found that HBZ activates expression of Heme Oxygenase 1 (HMOX-1), a component of the oxidative stress response that functions to detoxify free heme. Transcription of HMOX1 and other antioxidant genes is regulated by the small Mafs. These cellular basic leucine zipper (bZIP) factors control transcription by forming homo- or heterodimers among themselves or with other cellular bZIP factors that then bind Maf responsive elements (MAREs) in promoters or enhancers of antioxidant genes. Our data support a model in which HBZ activates HMOX1 transcription by forming heterodimers with the small Mafs that bind MAREs located in an upstream enhancer region. Consistent with this model, we found that HMOX-1 is upregulated in HTLV-1-transformed T-cell lines and confers these cells with resistance to heme-induced cytotoxicity. In this context, HBZ-mediated activation of HMOX-1 expression may contribute to resistance of ATL cells to certain chemotherapeutic agents. We also provide evidence that HBZ counteracts oxidative stress caused by two other HTLV-1-encoded proteins, Tax and p13. Tax induces oxidative stress as a byproduct of driving mitotic expansion of infected cells, and p13 is believed to induce oxidative stress to eliminate infected cells that have become transformed. Therefore, in this context, HBZ-mediated activation of HMOX-1 expression may facilitate transformation. Overall, this study characterizes a novel function of HBZ that may support the development and maintenance of ATL.
    URI
    http://hdl.handle.net/10342/8128
    Date
    2019-06-28
    Citation:
    APA:
    Rushing, Amanda W, & Rushing, Blake, & Hoang, Kimson, & Sanders, Stephanie V, & Péloponèse, Jean-Marie, & Polakowski, Nicholas, & Lemasson, Isabelle. (June 2019). HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLOS Pathogens, (. Retrieved from http://hdl.handle.net/10342/8128

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    MLA:
    Rushing, Amanda W, and Rushing, Blake, and Hoang, Kimson, and Sanders, Stephanie V, and Péloponèse, Jean-Marie, and Polakowski, Nicholas, and Lemasson, Isabelle. "HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I". PLOS Pathogens. . (.), June 2019. March 01, 2021. http://hdl.handle.net/10342/8128.
    Chicago:
    Rushing, Amanda W and Rushing, Blake and Hoang, Kimson and Sanders, Stephanie V and Péloponèse, Jean-Marie and Polakowski, Nicholas and Lemasson, Isabelle, "HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I," PLOS Pathogens , no. (June 2019), http://hdl.handle.net/10342/8128 (accessed March 01, 2021).
    AMA:
    Rushing, Amanda W, Rushing, Blake, Hoang, Kimson, Sanders, Stephanie V, Péloponèse, Jean-Marie, Polakowski, Nicholas, Lemasson, Isabelle. HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLOS Pathogens. June 2019; () . http://hdl.handle.net/10342/8128. Accessed March 01, 2021.
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