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    Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity

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    Author
    Friday, Andrew J.; Keiper, Brett D.
    Abstract
    Ultimately, the production of new proteins in undetermined cells pushes them to new fates. Other proteins hold a stem cell in a mode of self-renewal. In germ cells, these decision-making proteins are produced largely from translational control of preexisting mRNAs. To date, all of the regulation has been attributed to RNA binding proteins (RBPs) that repress mRNAs in many models of germ cell development (Drosophila, mouse, C. elegans, and Xenopus). In this review, we focus on the selective, positive function of translation initiation factors eIF4E and eIF4G, which recruit mRNAs to ribosomes upon derepression. Evidence now shows that the two events are not separate but rather are coordinated through composite complexes of repressors and germ cell isoforms of eIF4 factors. Strikingly, the initiation factor isoforms are themselves mRNA selective. The mRNP complexes of translation factors and RBPs are built on specific populations of mRNAs to prime them for subsequent translation initiation. Simple rearrangement of the partners causes a dormant mRNP to become synthetically active in germ cells when and where they are required to support gametogenesis.
    URI
    http://hdl.handle.net/10342/8163
    Date
    2015
    Citation:
    APA:
    Friday, Andrew J., & Keiper, Brett D.. (January 2015). Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity. , (), - . Retrieved from http://hdl.handle.net/10342/8163

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Friday, Andrew J., and Keiper, Brett D.. "Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity". . . (), January 2015. December 11, 2023. http://hdl.handle.net/10342/8163.
    Chicago:
    Friday, Andrew J. and Keiper, Brett D., "Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity," , no. (January 2015), http://hdl.handle.net/10342/8163 (accessed December 11, 2023).
    AMA:
    Friday, Andrew J., Keiper, Brett D.. Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity. . January 2015; (): . http://hdl.handle.net/10342/8163. Accessed December 11, 2023.
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