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    A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region

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    10.1186_1476-069X-13-54 (359.8Kb)

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    Author
    Schinasi, Leah; Wing, Steve; Augustino, Kerri L.; Ramsey, Keith M.; Nobles, Delores L.; Richardson, David B.; Price, Lance B.; Aziz, Maliha; MacDonald, Pia DM; Stewart, Jill R.
    Abstract
    Background: Distinct strains of methicillin resistant Staphylococcus aureus (MRSA) have been identified on livestock and livestock workers. Industrial food animal production may be an important environmental reservoir for human carriage of these pathogenic bacteria. The objective of this study was to investigate environmental and occupational exposures associated with nasal carriage of MRSA in patients hospitalized at Vidant Medical Center, a tertiary hospital serving a region with intensive livestock production in eastern North Carolina. Methods: MRSA nasal carriage was identified via nasal swabs collected within 24 hours of hospital admission. MRSA carriers (cases) were gender and age matched to non-carriers (controls). Participants were interviewed about recent environmental and occupational exposures. Home addresses were geocoded and publicly available data were used to estimate the density of swine in residential census block groups of residence. Conditional logistic regression models were used to derive odds ratio (OR) estimates and 95% confidence intervals (CI). Presence of the scn gene in MRSA isolates was assessed. In addition, multi locus sequence typing (MLST) of the MRSA isolates was performed, and the Diversilab® system was used to match the isolates to USA pulsed field gel electrophoresis types. Results: From July - December 2011, 117 cases and 119 controls were enrolled. A higher proportion of controls than cases were current workforce members (41.2% vs. 31.6%) Cases had a higher odds of living in census block groups with medium densities of swine (OR: 4.76, 95% CI: 1.36-16.69) and of reporting the ability to smell odor from a farm with animals when they were home (OR: 1.51, 95% CI: 0.80-2.86). Of 49 culture positive MRSA isolates, all were scn positive. Twenty-two isolates belonged to clonal complex 5. Conclusions: Absence of livestock workers in this study precluded evaluation of occupational exposures. Higher odds of MRSA in medium swine density areas could reflect environmental exposure to swine or poultry.
    URI
    http://hdl.handle.net/10342/8206
    Subject
    : Methicillin resistant Staphylococcus aureus, Livestock, Bacterial antibiotic resistance, Concentrated animal feeding operations, North Carolina
    Date
    2014
    Citation:
    APA:
    Schinasi, Leah, & Wing, Steve, & Augustino, Kerri L., & Ramsey, Keith M., & Nobles, Delores L., & Richardson, David B., & Price, Lance B., & Aziz, Maliha, & MacDonald, Pia DM, & Stewart, Jill R.. (January 2014). A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region. Environmental health : a global access science source, (13:1), p.. Retrieved from http://hdl.handle.net/10342/8206

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    MLA:
    Schinasi, Leah, and Wing, Steve, and Augustino, Kerri L., and Ramsey, Keith M., and Nobles, Delores L., and Richardson, David B., and Price, Lance B., and Aziz, Maliha, and MacDonald, Pia DM, and Stewart, Jill R.. "A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region". Environmental health : a global access science source. 13:1. (.), January 2014. April 14, 2021. http://hdl.handle.net/10342/8206.
    Chicago:
    Schinasi, Leah and Wing, Steve and Augustino, Kerri L. and Ramsey, Keith M. and Nobles, Delores L. and Richardson, David B. and Price, Lance B. and Aziz, Maliha and MacDonald, Pia DM and Stewart, Jill R., "A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region," Environmental health : a global access science source 13, no. 1 (January 2014), http://hdl.handle.net/10342/8206 (accessed April 14, 2021).
    AMA:
    Schinasi, Leah, Wing, Steve, Augustino, Kerri L., Ramsey, Keith M., Nobles, Delores L., Richardson, David B., Price, Lance B., Aziz, Maliha, MacDonald, Pia DM, Stewart, Jill R.. A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region. Environmental health : a global access science source. January 2014; 13(1) . http://hdl.handle.net/10342/8206. Accessed April 14, 2021.
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