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    Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner

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    Author
    Zawiślak, Alina; Jakimowicz, Piotr; McCubrey, James A.; Rakus, Dariusz
    Abstract
    It has been shown that neurons alter the expression of astrocytic metabolic enzymes by secretion of until now unknown molecule(s) into extracellular fluid. Here, we present evidence that neuron-derived transthyretin (TTR) stimulates expression of glycolytic enzymes in astrocytes which is reflected by an increased synthesis of ATP. The action of TTR is restricted to regulatory enzymes of glycolysis: phosphofructokinase P (PFKP) and pyruvate kinase M1/M2 isoforms (PKM1/2). The regulation of PFK and PKM expression by TTR is presumably specific for brain tissue and is independent of the role of TTR as a carrier protein for thyroxine and retinol. TTR induced expression of PKM and PFK is mediated by the cAMP/PKA-dependent pathway and is antagonized by the PI3K/Akt pathway. Our results provide the first experimental evidence for action of TTR as a neuron-derived energy metabolism activator in astrocytes and describe the mechanisms of its action. The data presented here suggest that TTR is involved in a mechanism in which neurons stimulate degradation of glycogen-derived glucosyl units without significant modulation of glucose uptake by glial cells.
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    http://hdl.handle.net/10342/8241
    Date
    2017-11-20
    Citation:
    APA:
    Zawiślak, Alina, & Jakimowicz, Piotr, & McCubrey, James A., & Rakus, Dariusz. (November 2017). Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner. Oncotarget, (8:63), p.106625-106638. Retrieved from http://hdl.handle.net/10342/8241

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Zawiślak, Alina, and Jakimowicz, Piotr, and McCubrey, James A., and Rakus, Dariusz. "Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner". Oncotarget. 8:63. (106625-106638.), November 2017. March 08, 2021. http://hdl.handle.net/10342/8241.
    Chicago:
    Zawiślak, Alina and Jakimowicz, Piotr and McCubrey, James A. and Rakus, Dariusz, "Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner," Oncotarget 8, no. 63 (November 2017), http://hdl.handle.net/10342/8241 (accessed March 08, 2021).
    AMA:
    Zawiślak, Alina, Jakimowicz, Piotr, McCubrey, James A., Rakus, Dariusz. Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner. Oncotarget. November 2017; 8(63) 106625-106638. http://hdl.handle.net/10342/8241. Accessed March 08, 2021.
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