Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females
Author
Winn, Nathan C.; Grunewald, Zachary I.; Liu, Ying; Heden, Timothy D.; Nyhoff, Lauren M.; Kanaley, Jill A.
Abstract
Background and Purpose
Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity bene- fits; yet its response during exercise in obese women is not described. This study character- ized plasma irisin levels during a single bout of afternoon isocaloric-exercise of different intensities (moderate- vs high-intensity) in obese females.
Methods
Eleven obese females participated in 3 randomized study days beginning at 1600h: 1) no exercise (NoEx), 2) moderate exercise (ModEx; 55%VO2max) and 3) high intensity interval exercise (IntEx; 4 min (80%VO2max)/3 min (50% VO2max). Frequent blood samples were analyzed for glucose and lactate (whole-blood), and insulin, c-peptide, glucagon, and irisin (plasma) throughout 190 min of testing.
Results
Plasma irisin increased above baseline during ModEx and IntEx (P<0.05), but not NoEx (P>0.05). Peak irisin levels during ModEx and IntEx exercise were 11.9± 3.4% and 12.3 ± 4.1% relative to baseline (P<0.05), respectively, with no differences between exercise inten- sities (P>0.05). Irisin levels remained elevated above resting for 125 minutes post-exercise during ModEx, whereas levels returned to baseline within 15 minutes post-exercise during IntEx. Similarly, no associations were found between plasma irisin levels and circulating lac- tate, glucose, insulin, c-peptide, or glucagon among study days (P>0.05). However, there was an inverse association between basal irisin and lean mass (r = -0.70, P = 0.01).
Conclusion
A single bout of moderate and high intensity afternoon exercise induces modest increases in circulating irisin concentrations during exercise; however the regulation post-exercise appears to be dimorphic between exercise intensity in obese females. Future studies are needed to compare morning and afternoon exercise on irisin secretion.
Date
2017-01-26
Citation:
APA:
Winn, Nathan C., & Grunewald, Zachary I., & Liu, Ying, & Heden, Timothy D., & Nyhoff, Lauren M., & Kanaley, Jill A.. (January 2017).
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8258
MLA:
Winn, Nathan C., and Grunewald, Zachary I., and Liu, Ying, and Heden, Timothy D., and Nyhoff, Lauren M., and Kanaley, Jill A..
"Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females". .
. (),
January 2017.
September 28, 2023.
http://hdl.handle.net/10342/8258.
Chicago:
Winn, Nathan C. and Grunewald, Zachary I. and Liu, Ying and Heden, Timothy D. and Nyhoff, Lauren M. and Kanaley, Jill A.,
"Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females," , no.
(January 2017),
http://hdl.handle.net/10342/8258 (accessed
September 28, 2023).
AMA:
Winn, Nathan C., Grunewald, Zachary I., Liu, Ying, Heden, Timothy D., Nyhoff, Lauren M., Kanaley, Jill A..
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females. .
January 2017;
():
.
http://hdl.handle.net/10342/8258. Accessed
September 28, 2023.
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