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    Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function

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    Author
    McDaniel, Dylan K.; Ringel-Scaia, Veronica M.; Morrison, Holly A.; Coutermarsh-Ott, Sheryl; Council-Troche, McAlister; Angle, Jonathan W.; Perry, Justin B.; Davis, Grace; Leng, Weinan; Minarchick, Valerie; Yang, Yi; Chen, Bo; Reece, Sky W.; Brown, David A.; Cecere, Thomas E.; Brown, Jared M.; Gowdy, Kymberly M.; Hochella, Michael F.; Allen, Irving C.
    Abstract
    Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of otherwise rare Magnéli phase titanium suboxides from TiO2 minerals naturally present in coal. These nanoscale Magnéli phases are biologically active without photostimulation and toxic to airway epithelial cells in vitro and to zebrafish in vivo. Here, we sought to determine the clinical and physiological impact of pulmonary exposure to Magnéli phases using mice as mammalian model organisms. Mice were exposed to the most frequently found Magnéli phases, Ti6O11, at 100 parts per million (ppm) via intratracheal administration. Local and systemic titanium concentrations, lung pathology, and changes in airway mechanics were assessed. Additional mechanistic studies were conducted with primary bone marrow derived macrophages. Our results indicate that macrophages are the cell type most impacted by exposure to these nanoscale particles. Following phagocytosis, macrophages fail to properly eliminate Magnéli phases, resulting in increased oxidative stress, mitochondrial dysfunction, and ultimately apoptosis. In the lungs, these nanoparticles become concentrated in macrophages, resulting in a feedback loop of reactive oxygen species production, cell death, and the initiation of gene expression profiles consistent with lung injury within 6 weeks of exposure. Chronic exposure and accumulation of Magnéli phases ultimately results in significantly reduced lung function impacting airway resistance, compliance, and elastance. Together, these studies demonstrate that Magnéli phases are toxic in the mammalian airway and are likely a significant nanoscale environmental pollutant, especially in geographic regions where coal combustion is a major contributor to atmospheric particulate matter.
    URI
    http://hdl.handle.net/10342/8271
    Subject
    cytotoxicity, air pollution, nanoparticle, TixO2x−1, in vivo, environmental exposure
    Date
    2019-11-28
    Citation:
    APA:
    McDaniel, Dylan K., & Ringel-Scaia, Veronica M., & Morrison, Holly A., & Coutermarsh-Ott, Sheryl, & Council-Troche, McAlister, & Angle, Jonathan W., & Perry, Justin B., & Davis, Grace, & Leng, Weinan, & Minarchick, Valerie, & Yang, Yi, & Chen, Bo, & Reece, Sky W., & Brown, David A., & Cecere, Thomas E., & Brown, Jared M., & Gowdy, Kymberly M., & Hochella, Michael F., & Allen, Irving C.. (November 2019). Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function. Frontiers in Immunology, (10:2714), p.. Retrieved from http://hdl.handle.net/10342/8271

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    McDaniel, Dylan K., and Ringel-Scaia, Veronica M., and Morrison, Holly A., and Coutermarsh-Ott, Sheryl, and Council-Troche, McAlister, and Angle, Jonathan W., and Perry, Justin B., and Davis, Grace, and Leng, Weinan, and Minarchick, Valerie, and Yang, Yi, and Chen, Bo, and Reece, Sky W., and Brown, David A., and Cecere, Thomas E., and Brown, Jared M., and Gowdy, Kymberly M., and Hochella, Michael F., and Allen, Irving C.. "Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function". Frontiers in Immunology. 10:2714. (.), November 2019. April 19, 2021. http://hdl.handle.net/10342/8271.
    Chicago:
    McDaniel, Dylan K. and Ringel-Scaia, Veronica M. and Morrison, Holly A. and Coutermarsh-Ott, Sheryl and Council-Troche, McAlister and Angle, Jonathan W. and Perry, Justin B. and Davis, Grace and Leng, Weinan and Minarchick, Valerie and Yang, Yi and Chen, Bo and Reece, Sky W. and Brown, David A. and Cecere, Thomas E. and Brown, Jared M. and Gowdy, Kymberly M. and Hochella, Michael F. and Allen, Irving C., "Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function," Frontiers in Immunology 10, no. 2714 (November 2019), http://hdl.handle.net/10342/8271 (accessed April 19, 2021).
    AMA:
    McDaniel, Dylan K., Ringel-Scaia, Veronica M., Morrison, Holly A., Coutermarsh-Ott, Sheryl, Council-Troche, McAlister, Angle, Jonathan W., Perry, Justin B., Davis, Grace, Leng, Weinan, Minarchick, Valerie, Yang, Yi, Chen, Bo, Reece, Sky W., Brown, David A., Cecere, Thomas E., Brown, Jared M., Gowdy, Kymberly M., Hochella, Michael F., Allen, Irving C.. Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function. Frontiers in Immunology. November 2019; 10(2714) . http://hdl.handle.net/10342/8271. Accessed April 19, 2021.
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