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    Pineal Region Glioblastoma, a Case Report and Literature Review

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    Author
    Stowe, Hayley Beacher; Miller, C. Ryan; Wu, Jing; Randazzo, Dina M.; Ju, Andrew Wenhua
    Abstract
    Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with favorable outcome. Case background: A 65-year-old patient who was presented with visual symptoms was found to have a pineal region tumor on imaging. A stereotactic biopsy showed a World Health Organization Grade IV GBM, O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylated, isocitrate dehydrogenase 1 and 2 wild type. The patient was treated with radiotherapy with concurrent temozolomide, followed by adjuvant temozolomide. Disease progression occurred at 58 weeks post-biopsy, which prompted the initiation of bevacizumab. The patient was alive and functioning well as of his last follow up, 166 weeks from the initial biopsy. Discussion: On our review of the literature, 24 cases of pineal region GBM have been reported. The median reported survival for these previously reported cases was 6 months (range, 2–24 months). This patient has the longest overall survival reported to date for a patient with this diagnosis. This is the first patient in the literature with pineal region GBM who has been reported to have MGMT promoter methylation. Concluding remarks: Although pineal region GBM is a rare disease entity with a gener- ally poor prognosis, long-term survival is achievable for select patients. MGMT promoter methylation may potentially have prognostic value. Favorable control of recurrent disease with the use of bevacizumab is possible.
    URI
    http://hdl.handle.net/10342/8275
    Date
    2017-06-12
    Citation:
    APA:
    Stowe, Hayley Beacher, & Miller, C. Ryan, & Wu, Jing, & Randazzo, Dina M., & Ju, Andrew Wenhua. (June 2017). Pineal Region Glioblastoma, a Case Report and Literature Review. Frontiers in Oncology, (. Retrieved from http://hdl.handle.net/10342/8275

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Stowe, Hayley Beacher, and Miller, C. Ryan, and Wu, Jing, and Randazzo, Dina M., and Ju, Andrew Wenhua. "Pineal Region Glioblastoma, a Case Report and Literature Review". Frontiers in Oncology. . (.), June 2017. August 17, 2022. http://hdl.handle.net/10342/8275.
    Chicago:
    Stowe, Hayley Beacher and Miller, C. Ryan and Wu, Jing and Randazzo, Dina M. and Ju, Andrew Wenhua, "Pineal Region Glioblastoma, a Case Report and Literature Review," Frontiers in Oncology 7, no. (June 2017), http://hdl.handle.net/10342/8275 (accessed August 17, 2022).
    AMA:
    Stowe, Hayley Beacher, Miller, C. Ryan, Wu, Jing, Randazzo, Dina M., Ju, Andrew Wenhua. Pineal Region Glioblastoma, a Case Report and Literature Review. Frontiers in Oncology. June 2017; 7() . http://hdl.handle.net/10342/8275. Accessed August 17, 2022.
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