Pineal Region Glioblastoma, a Case Report and Literature Review
Author
Stowe, Hayley Beacher; Miller, C. Ryan; Wu, Jing; Randazzo, Dina M.; Ju, Andrew Wenhua
Abstract
Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with favorable outcome.
Case background: A 65-year-old patient who was presented with visual symptoms was found to have a pineal region tumor on imaging. A stereotactic biopsy showed a World Health Organization Grade IV GBM, O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylated, isocitrate dehydrogenase 1 and 2 wild type. The patient was treated with radiotherapy with concurrent temozolomide, followed by adjuvant temozolomide. Disease progression occurred at 58 weeks post-biopsy, which prompted the initiation of bevacizumab. The patient was alive and functioning well as of his last follow up, 166 weeks from the initial biopsy.
Discussion: On our review of the literature, 24 cases of pineal region GBM have been reported. The median reported survival for these previously reported cases was 6 months (range, 2–24 months). This patient has the longest overall survival reported to date for a patient with this diagnosis. This is the first patient in the literature with pineal region GBM who has been reported to have MGMT promoter methylation.
Concluding remarks: Although pineal region GBM is a rare disease entity with a gener- ally poor prognosis, long-term survival is achievable for select patients. MGMT promoter methylation may potentially have prognostic value. Favorable control of recurrent disease with the use of bevacizumab is possible.
Date
2017-06-12
Citation:
APA:
Stowe, Hayley Beacher, & Miller, C. Ryan, & Wu, Jing, & Randazzo, Dina M., & Ju, Andrew Wenhua. (June 2017).
Pineal Region Glioblastoma, a Case Report and Literature Review.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8275
MLA:
Stowe, Hayley Beacher, and Miller, C. Ryan, and Wu, Jing, and Randazzo, Dina M., and Ju, Andrew Wenhua.
"Pineal Region Glioblastoma, a Case Report and Literature Review". .
. (),
June 2017.
June 29, 2024.
http://hdl.handle.net/10342/8275.
Chicago:
Stowe, Hayley Beacher and Miller, C. Ryan and Wu, Jing and Randazzo, Dina M. and Ju, Andrew Wenhua,
"Pineal Region Glioblastoma, a Case Report and Literature Review," , no.
(June 2017),
http://hdl.handle.net/10342/8275 (accessed
June 29, 2024).
AMA:
Stowe, Hayley Beacher, Miller, C. Ryan, Wu, Jing, Randazzo, Dina M., Ju, Andrew Wenhua.
Pineal Region Glioblastoma, a Case Report and Literature Review. .
June 2017;
():
.
http://hdl.handle.net/10342/8275. Accessed
June 29, 2024.
Collections