Real-time compression feedback for patients with in-hospital cardiac arrest: a multi-center randomized controlled clinical trial
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Date
2019-01-03
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Authors
Goharani, Reza
Vahedian-Azimi, Amir
Farzanegan, Behrooz
Bashar, Farshid R.
Hajiesmaeili, Mohammadreza
Shojae, Seyedpouzhia
Madani, Seyed J.
Gohari-Moghaddam, Keivan
Hatamian, Sevak
Mosavinasab, Seyed M. M.
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Abstract
Objective: To determine if real-time compression feedback using a non-automated hand-held device improves
patient outcomes from in-hospital cardiac arrest (IHCA).
Methods: We conducted a prospective, randomized, controlled, parallel study (no crossover) of patients with IHCA in
the mixed medical–surgical intensive care units (ICUs) of eight academic hospitals. Patients received either standard
manual chest compressions or compressions performed with real-time feedback using the Cardio First Angel™ (CFA)
device. The primary outcome was sustained return of spontaneous circulation (ROSC), and secondary outcomes were
survival to ICU and hospital discharge.
Results: One thousand four hundred fifty-four subjects were randomized; 900 were included. Sustained ROSC was
significantly improved in the CFA group (66.7% vs. 42.4%, P < 0.001), as was survival to ICU discharge (59.8% vs. 33.6%)
and survival to hospital discharge (54% vs. 28.4%, P < 0.001). Outcomes were not affected by intra-group comparisons
based on intubation status. ROSC, survival to ICU, and hospital discharge were noted to be improved in inter-group
comparisons of non-intubated patients, but not intubated ones.
Conclusion: Use of the CFA compression feedback device improved event survival and survival to ICU and hospital
discharge.
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DOI
10.1186/s40560-019-0357-5