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    Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report

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    Author
    Gonzales, Mia; Pipalia, Amrish; Weil, Andrew
    Abstract
    Heparin-induced thrombocytopenia (HIT) type II is caused by antibody production that bind complexes between heparin and platelet factor 4 leading to platelet consumption and thrombosis. In a small subset of cases referred to as autoimmune HIT, the antibodies activate platelets even in the absence of heparin. Refractory HIT is a type of autoimmune HIT in which thrombocytopenia persists for weeks after heparin discontinuation and carries increased risk for thrombosis and more severe thrombocytopenia. We present a case of refractory HIT with cerebral venous sinus thrombosis (CVST) that was successfully treated with a change in anticoagulant alongside steroids and a second trial of intravenous immunoglobulin (IVIg).
    URI
    http://hdl.handle.net/10342/8296
    Subject
    heparin-induced thrombocytopenia, cerebral venous sinus thrombosis, IVIg, refractory HIT, autoimmune HIT
    Date
    2019-04-02
    Citation:
    APA:
    Gonzales, Mia, & Pipalia, Amrish, & Weil, Andrew. (April 2019). Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report. , (), - . Retrieved from http://hdl.handle.net/10342/8296

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Gonzales, Mia, and Pipalia, Amrish, and Weil, Andrew. "Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report". . . (), April 2019. October 03, 2023. http://hdl.handle.net/10342/8296.
    Chicago:
    Gonzales, Mia and Pipalia, Amrish and Weil, Andrew, "Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report," , no. (April 2019), http://hdl.handle.net/10342/8296 (accessed October 03, 2023).
    AMA:
    Gonzales, Mia, Pipalia, Amrish, Weil, Andrew. Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report. . April 2019; (): . http://hdl.handle.net/10342/8296. Accessed October 03, 2023.
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