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    The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species

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    Author
    Curtis II, Alan D.; Taslim, Najla; Reece, Shaun P.; Grebenciucova, Elena; Ray, Richard H.; Rosenbaum, Matthew D.; Wardle, Robert L.; Van Scott, Michael R.; Mannie, Mark D.
    Abstract
    Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical EAE feature stereotypic progression of an ascending flaccid paralysis that is not a characteristic of MS. The study of atypical EAE however has been limited due to the relative lack of suitable models that feature reliable disease incidence and severity, excepting mice deficient in gamma-interferon signaling pathways. In this study, atypical EAE was induced in Lewis rats, and a related approach was effective for induction of an unusual neurologic syndrome in a cynomolgus macaque. Lewis rats were immunized with the rat immunoglobulin variable (IgV)-related extracellular domain of myelin oligodendrocyte glycoprotein (IgV-MOG) in complete Freund’s adjuvant (CFA) followed by one or more injections of rat IgV-MOG in incomplete Freund’s adjuvant (IFA). The resulting disease was marked by torticollis, unilateral rigid paralysis, forelimb weakness, and high titers of anti-MOG antibody against conformational epitopes of MOG, as well as other signs of atypical EAE. A similar strategy elicited a distinct atypical form of EAE in a cynomolgus macaque. By day 36 in the monkey, titers of IgG against conformational epitopes of extracellular MOG were evident, and on day 201, the macaque had an abrupt onset of an unusual form of EAE that included a pronounced arousal-dependent, transient myotonia. The disease persisted for 6–7 weeks and was marked by a gradual, consistent improvement and an eventual full recovery without recurrence. These data indicate that one or more boosters of IgV-MOG in IFA represent a key variable for induction of atypical or unusual forms of EAE in rat and Macaca species. These studies also reveal a close correlation between humoral immunity against conformational epitopes of MOG, extended confluent demyelinating plaques in spinal cord and brainstem, and atypical disease induction.
    URI
    http://hdl.handle.net/10342/8298
    Date
    2014-10-14
    Citation:
    APA:
    Curtis II, Alan D., & Taslim, Najla, & Reece, Shaun P., & Grebenciucova, Elena, & Ray, Richard H., & Rosenbaum, Matthew D., & Wardle, Robert L., & Van Scott, Michael R., & Mannie, Mark D.. (October 2014). The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species. PLoS ONE, (9:10), p.1-17. Retrieved from http://hdl.handle.net/10342/8298

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    MLA:
    Curtis II, Alan D., and Taslim, Najla, and Reece, Shaun P., and Grebenciucova, Elena, and Ray, Richard H., and Rosenbaum, Matthew D., and Wardle, Robert L., and Van Scott, Michael R., and Mannie, Mark D.. "The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species". PLoS ONE. 9:10. (1-17.), October 2014. April 19, 2021. http://hdl.handle.net/10342/8298.
    Chicago:
    Curtis II, Alan D. and Taslim, Najla and Reece, Shaun P. and Grebenciucova, Elena and Ray, Richard H. and Rosenbaum, Matthew D. and Wardle, Robert L. and Van Scott, Michael R. and Mannie, Mark D., "The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species," PLoS ONE 9, no. 10 (October 2014), http://hdl.handle.net/10342/8298 (accessed April 19, 2021).
    AMA:
    Curtis II, Alan D., Taslim, Najla, Reece, Shaun P., Grebenciucova, Elena, Ray, Richard H., Rosenbaum, Matthew D., Wardle, Robert L., Van Scott, Michael R., Mannie, Mark D.. The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species. PLoS ONE. October 2014; 9(10) 1-17. http://hdl.handle.net/10342/8298. Accessed April 19, 2021.
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