• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila

    Thumbnail
    View/ Open
    1-s2.0-S001216061830592X-main.pdf (3.549Mb)

    Show full item record
    Author
    Basar, Mohammed Abul; Williamson, Kishana; Roy, Swagota D.; Danielle S., Finger; Ables, Elizabeth Tweedie; Duttaroy, Atanu
    Abstract
    Dietary proteins are crucial for oogenesis. The Target of Rapamycin (TOR) is a major nutrient sensor controlling organismal growth and fertility, but the downstream effectors of TOR signaling remain largely uncharacterized. We previously identified Drosophila Spargel/dPGC-1 as a terminal effector of the TOR-TSC pathway, and now report that Spargel connects nutrition to oogenesis. We found that Spargel is expressed predominantly in the ovaries of adult flies, and germline spargel knockdown inhibits cyst growth, ultimately leading to egg chamber degeneration and female sterility. In situ staining demonstrated nuclear localization of Spargel in the nurse cells and follicle cells of the ovariole. Furthermore, Spargel/dPGC-1 expression is influenced by dietary yeast concentration and TOR signaling, suggesting Spargel/dPGC-1 might transmit nutrient-mediated signals into ovarian growth. We propose that potentiating Spargel/dPGC-1 expression in the ovary is instrumental in nutrient-mediated regulation of oogenesis.
    URI
    http://hdl.handle.net/10342/8332
    Subject
    Spargel; PGC-1; Drosophila; Nutrition; Insulin; TOR
    Date
    2019-06-25
    Citation:
    APA:
    Basar, Mohammed Abul, & Williamson, Kishana, & Roy, Swagota D., & Danielle S., Finger, & Ables, Elizabeth Tweedie, & Duttaroy, Atanu. (June 2019). Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila. , (), - . Retrieved from http://hdl.handle.net/10342/8332

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Basar, Mohammed Abul, and Williamson, Kishana, and Roy, Swagota D., and Danielle S., Finger, and Ables, Elizabeth Tweedie, and Duttaroy, Atanu. "Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila". . . (), June 2019. September 29, 2023. http://hdl.handle.net/10342/8332.
    Chicago:
    Basar, Mohammed Abul and Williamson, Kishana and Roy, Swagota D. and Danielle S., Finger and Ables, Elizabeth Tweedie and Duttaroy, Atanu, "Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila," , no. (June 2019), http://hdl.handle.net/10342/8332 (accessed September 29, 2023).
    AMA:
    Basar, Mohammed Abul, Williamson, Kishana, Roy, Swagota D., Danielle S., Finger, Ables, Elizabeth Tweedie, Duttaroy, Atanu. Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila. . June 2019; (): . http://hdl.handle.net/10342/8332. Accessed September 29, 2023.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback