Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila
Author
Basar, Mohammed Abul; Williamson, Kishana; Roy, Swagota D.; Danielle S., Finger; Ables, Elizabeth Tweedie; Duttaroy, Atanu
Abstract
Dietary proteins are crucial for oogenesis. The Target of Rapamycin (TOR) is a major nutrient sensor controlling organismal growth and fertility, but the downstream effectors of TOR signaling remain largely uncharacterized. We previously identified Drosophila Spargel/dPGC-1 as a terminal effector of the TOR-TSC pathway, and now report that Spargel connects nutrition to oogenesis. We found that Spargel is expressed predominantly in the ovaries of adult flies, and germline spargel knockdown inhibits cyst growth, ultimately leading to egg chamber degeneration and female sterility. In situ staining demonstrated nuclear localization of Spargel in the nurse cells and follicle cells of the ovariole. Furthermore, Spargel/dPGC-1 expression is influenced by dietary yeast concentration and TOR signaling, suggesting Spargel/dPGC-1 might transmit nutrient-mediated signals into ovarian growth. We propose that potentiating Spargel/dPGC-1 expression in the ovary is instrumental in nutrient-mediated regulation of oogenesis.
Date
2019-06-25
Citation:
APA:
Basar, Mohammed Abul, & Williamson, Kishana, & Roy, Swagota D., & Danielle S., Finger, & Ables, Elizabeth Tweedie, & Duttaroy, Atanu. (June 2019).
Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8332
MLA:
Basar, Mohammed Abul, and Williamson, Kishana, and Roy, Swagota D., and Danielle S., Finger, and Ables, Elizabeth Tweedie, and Duttaroy, Atanu.
"Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila". .
. (),
June 2019.
September 29, 2023.
http://hdl.handle.net/10342/8332.
Chicago:
Basar, Mohammed Abul and Williamson, Kishana and Roy, Swagota D. and Danielle S., Finger and Ables, Elizabeth Tweedie and Duttaroy, Atanu,
"Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila," , no.
(June 2019),
http://hdl.handle.net/10342/8332 (accessed
September 29, 2023).
AMA:
Basar, Mohammed Abul, Williamson, Kishana, Roy, Swagota D., Danielle S., Finger, Ables, Elizabeth Tweedie, Duttaroy, Atanu.
Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila. .
June 2019;
():
.
http://hdl.handle.net/10342/8332. Accessed
September 29, 2023.
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