Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies
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Date
2019-03-15
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Authors
Horton, Julie L.
Virag, Jitka
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Abstract
Myocardial tissue damage that occurs during an ischemic event leads to a spiraling
deterioration of cardiac muscle structural and functional integrity. Reperfusion is the only known
efficacious strategy and is the most commonly used treatment to reduce injury and prevent
remodeling. However, timing is critical, and the procedure is not always feasible for a variety
of reasons. The complex molecular basis for cardioprotection has been studied for decades but
formulation of a viable therapeutic that can significantly attenuate myocardial injury remains elusive.
In this review, we address barriers to the development of a fruitful approach that will substantially
improve the prognosis of those suffering from this widespread and largely unmitigated disease.
Furthermore, we proffer that ephrinA1, a candidate molecule that satisfies many of the important
criteria discussed, possesses robust potential to overcome these hurdles and thus offers protection
that surpasses the limitations currently observed.
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DOI
10.3390/ijms20061449