| Description | α-Klotho, a multifunctional protein, has been demonstrated to protect tissues from
injury via anti-oxidation and anti-inflammatory effects. The expression of α-klotho is
regulated by several physiological and pathological factors, including acute inflammatory
stress, oxidative stress, hypertension, and chronic renal failure. Exhaustive exercise has
been reported to result in tissue damage, which is induced by inflammation, oxidative
stress, and energy metabolism disturbance. However, little is known about the effects
of exhaustive exercise on the expression of α-klotho in various tissues. To determine the
effects, the treadmill exhaustion test in mice was performed and the mice were sacrificed
at different time points following exhaustive exercise. Our results confirmed that the
full-length (130 kDa) and shorter-form (65 kDa) α-klotho were primarily expressed in
the kidneys. Moreover, we found that, except for the kidneys and brain, other tissues
primarily expressed the shorter-form α-klotho, including liver, which was in contrast to
previous reports. Furthermore, the shorter-form α-klotho was decreased immediately
following the acute exhaustive exercise and was then restored to the pre-exercise level
or even higher levels in the next few days. Our results indicate that α-klotho may play a
key role in the body exhaustion and recovery following exhaustive exercise. | en_US |
