Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells

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Yoon, Dong Suk; Choi, Yoorim; Cha, Dong Seok; Zhang, Peng; Choi, Seong Mi; Alfhili, Mohammad A.; Polli, Joseph Ryan; Pendergrass, DeQwon; Taki, Faten A.; Kapalavavi, Brahmam; Pan, Xiaoping; Zhang, Baohong; Blackwell, T. Keith; Lee, Jin Woo; Lee, Myon-Hee
Abstract
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress response. Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dependent manner. Cellular analysis showed that TCS inhibited the nuclear localization of SKN-1/Nrf2 and the expression of its target genes, which were associated with oxidative stress response. Notably, TCS-induced toxicity was significantly reduced by either antioxidant treatment or constitutive SKN-1/Nrf2 activation. As Nrf2 is strongly associated with aging and chemoresistance, these findings will provide a novel approach to the identification of therapeutic targets and disease treatment.
URI
http://hdl.handle.net/10342/8426
Date
2017-10-03
Citation:
APA:
Yoon, Dong Suk, & Choi, Yoorim, & Cha, Dong Seok, & Zhang, Peng, & Choi, Seong Mi, & Alfhili, Mohammad A., & Polli, Joseph Ryan, & Pendergrass, DeQwon, & Taki, Faten A., & Kapalavavi, Brahmam, & Pan, Xiaoping, & Zhang, Baohong, & Blackwell, T. Keith, & Lee, Jin Woo, & Lee, Myon-Hee. (October 2017). Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells. , (), - . Retrieved from http://hdl.handle.net/10342/8426

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MLA:
Yoon, Dong Suk, and Choi, Yoorim, and Cha, Dong Seok, and Zhang, Peng, and Choi, Seong Mi, and Alfhili, Mohammad A., and Polli, Joseph Ryan, and Pendergrass, DeQwon, and Taki, Faten A., and Kapalavavi, Brahmam, and Pan, Xiaoping, and Zhang, Baohong, and Blackwell, T. Keith, and Lee, Jin Woo, and Lee, Myon-Hee. "Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells". . . (), October 2017. September 21, 2023. http://hdl.handle.net/10342/8426.
Chicago:
Yoon, Dong Suk and Choi, Yoorim and Cha, Dong Seok and Zhang, Peng and Choi, Seong Mi and Alfhili, Mohammad A. and Polli, Joseph Ryan and Pendergrass, DeQwon and Taki, Faten A. and Kapalavavi, Brahmam and Pan, Xiaoping and Zhang, Baohong and Blackwell, T. Keith and Lee, Jin Woo and Lee, Myon-Hee, "Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells," , no. (October 2017), http://hdl.handle.net/10342/8426 (accessed September 21, 2023).
AMA:
Yoon, Dong Suk, Choi, Yoorim, Cha, Dong Seok, Zhang, Peng, Choi, Seong Mi, Alfhili, Mohammad A., Polli, Joseph Ryan, Pendergrass, DeQwon, Taki, Faten A., Kapalavavi, Brahmam, Pan, Xiaoping, Zhang, Baohong, Blackwell, T. Keith, Lee, Jin Woo, Lee, Myon-Hee. Triclosan Disrupts SKN-1/Nrf2- Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells. . October 2017; (): . http://hdl.handle.net/10342/8426. Accessed September 21, 2023.
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