A Micro-Thermal Sensor for Focal Therapy Applications
Natesan, Harishankar; Hodges, Wyatt; Choi, Jeunghwan; Lubner, Sean; Dames, Chris; Bischof, John
There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters).
Natesan, Harishankar, & Hodges, Wyatt, & Choi, Jeunghwan, & Lubner, Sean, & Dames, Chris, & Bischof, John. (February 2016). A Micro-Thermal Sensor for Focal Therapy Applications. Scientific Reports, (6:1), p.. Retrieved from http://hdl.handle.net/10342/8437
Natesan, Harishankar, and Hodges, Wyatt, and Choi, Jeunghwan, and Lubner, Sean, and Dames, Chris, and Bischof, John. "A Micro-Thermal Sensor for Focal Therapy Applications". Scientific Reports. 6:1. (.), February 2016. December 05, 2020. http://hdl.handle.net/10342/8437.
Natesan, Harishankar and Hodges, Wyatt and Choi, Jeunghwan and Lubner, Sean and Dames, Chris and Bischof, John, "A Micro-Thermal Sensor for Focal Therapy Applications," Scientific Reports 6, no. 1 (February 2016), http://hdl.handle.net/10342/8437 (accessed December 05, 2020).
Natesan, Harishankar, Hodges, Wyatt, Choi, Jeunghwan, Lubner, Sean, Dames, Chris, Bischof, John. A Micro-Thermal Sensor for Focal Therapy Applications. Scientific Reports. February 2016; 6(1) . http://hdl.handle.net/10342/8437. Accessed December 05, 2020.