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    The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

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    Author
    Tran, Tuan D.; Amin, Aenia; Jones, Keith G.; Sheffer, Ellen M.; Ortega, Lidia; Dolman, Keith
    Abstract
    Neonatal rats were administered a relatively high concentration of ethyl alcohol (11.9% v/v) during postnatal days 4-9, a time when the fetal brain undergoes rapid organizational change and is similar to accelerated brain changes that occur during the third trimester in humans. This model of fetal alcohol spectrum disorders (FASDs) produces severe brain damage, mimicking the amount and pattern of binge-drinking that occurs in some pregnant alcoholic mothers. We describe the use of trace eyeblink classical conditioning (ECC), a higher-order variant of associative learning, to assess long-term hippocampal dysfunction that is typically seen in alcohol-exposed adult offspring. At 90 days of age, rodents were surgically prepared with recording and stimulating electrodes, which measured electromyographic (EMG) blink activity from the left eyelid muscle and delivered mild shock posterior to the left eye, respectively. After a 5 day recovery period, they underwent 6 sessions of trace ECC to determine associative learning differences between alcohol-exposed and control rats. Trace ECC is one of many possible ECC procedures that can be easily modified using the same equipment and software, so that different neural systems can be assessed. ECC procedures in general, can be used as diagnostic tools for detecting neural pathology in different brain systems and different conditions that insult the brain.
    URI
    http://hdl.handle.net/10342/8458
    Date
    2017-08-05
    Citation:
    APA:
    Tran, Tuan D., & Amin, Aenia, & Jones, Keith G., & Sheffer, Ellen M., & Ortega, Lidia, & Dolman, Keith. (August 2017). The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders. Journal of Visualized Experiments, (. Retrieved from http://hdl.handle.net/10342/8458

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Tran, Tuan D., and Amin, Aenia, and Jones, Keith G., and Sheffer, Ellen M., and Ortega, Lidia, and Dolman, Keith. "The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders". Journal of Visualized Experiments. . (.), August 2017. August 07, 2022. http://hdl.handle.net/10342/8458.
    Chicago:
    Tran, Tuan D. and Amin, Aenia and Jones, Keith G. and Sheffer, Ellen M. and Ortega, Lidia and Dolman, Keith, "The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders," Journal of Visualized Experiments , no. 126 (August 2017), http://hdl.handle.net/10342/8458 (accessed August 07, 2022).
    AMA:
    Tran, Tuan D., Amin, Aenia, Jones, Keith G., Sheffer, Ellen M., Ortega, Lidia, Dolman, Keith. The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders. Journal of Visualized Experiments. August 2017; (126) . http://hdl.handle.net/10342/8458. Accessed August 07, 2022.
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