• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Clinical and echocardiographic predictors of mortality in acute pulmonary embolism

    Thumbnail
    View/ Open
    s12947-016-0087-y.pdf (724.2Kb)

    Show full item record
    
    Author
    Dahhan, Talal; Siddiqui, Irfan; Tapson, Victor F.; Velazquez, Eric J.; Sun, Stephanie; Davenport, Clemontina A.; Samad, Zainab; Rajagopal, Sudarshan
    Abstract
    Purpose: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism (PE). Methods: Patients with a diagnosis of acute PE, based on a positive ventilation perfusion scan or computed tomography (CT) chest angiogram, were identified using the Duke University Hospital Database. Of these, 69 had echocardiograms within 24–48 h of the diagnosis that were suitable for offline analysis. Clinical features that were analyzed included age, gender, body mass index, vital signs and comorbidities. Echocardiographic parameters that were analyzed included left ventricular (LV) ejection fraction (EF), regional, free wall and global RV speckle-tracking strain, RV fraction area change (RVFAC), Tricuspid Annular Plane Systolic Excursion (TAPSE), pulmonary artery acceleration time (PAAT) and RV myocardial performance (Tei) index. Univariable and multivariable regression statistical analysis models were used. Results: Out of 69 patients with acute PE, the median age was 55 and 48 % were female. The median body mass 2 index (BMI) was 27 kg/m . Twenty-nine percent of the cohort had a history of cancer, with a significant increase in cancer prevalence in non-survivors (57 % vs 29 %, p = 0.02). Clinical parameters including heart rate, respiratory rate, troponin T level, active malignancy, hypertension and COPD were higher among non-survivors when compared to survivors (p ≤ 0.05). Using univariable analysis, NYHA class III symptoms, hypoxemia on presentation, tachycardia, tachypnea, elevation in Troponin T, absence of hypertension, active malignancy and chronic obstructive pulmonary disease (COPD) were increased in non-survivors compared to survivors (p ≤ 0.05). In multivariable models, RV Tei Index, global and free (lateral) wall RVLS were found to be negatively associated with survival probability after adjusting for age, gender and systolic blood pressure (p ≤ 0.05). Conclusion: The addition of echocardiographic assessment of RV function to clinical parameters improved the prediction of outcomes for patients with acute PE. Larger studies are needed to validate these findings.
    URI
    http://hdl.handle.net/10342/8461
    Date
    2016-10-28
    Citation:
    APA:
    Dahhan, Talal, & Siddiqui, Irfan, & Tapson, Victor F., & Velazquez, Eric J., & Sun, Stephanie, & Davenport, Clemontina A., & Samad, Zainab, & Rajagopal, Sudarshan. (October 2016). Clinical and echocardiographic predictors of mortality in acute pulmonary embolism. Cardiovascular Ultrasound, (14:1), p.. Retrieved from http://hdl.handle.net/10342/8461

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Dahhan, Talal, and Siddiqui, Irfan, and Tapson, Victor F., and Velazquez, Eric J., and Sun, Stephanie, and Davenport, Clemontina A., and Samad, Zainab, and Rajagopal, Sudarshan. "Clinical and echocardiographic predictors of mortality in acute pulmonary embolism". Cardiovascular Ultrasound. 14:1. (.), October 2016. February 26, 2021. http://hdl.handle.net/10342/8461.
    Chicago:
    Dahhan, Talal and Siddiqui, Irfan and Tapson, Victor F. and Velazquez, Eric J. and Sun, Stephanie and Davenport, Clemontina A. and Samad, Zainab and Rajagopal, Sudarshan, "Clinical and echocardiographic predictors of mortality in acute pulmonary embolism," Cardiovascular Ultrasound 14, no. 1 (October 2016), http://hdl.handle.net/10342/8461 (accessed February 26, 2021).
    AMA:
    Dahhan, Talal, Siddiqui, Irfan, Tapson, Victor F., Velazquez, Eric J., Sun, Stephanie, Davenport, Clemontina A., Samad, Zainab, Rajagopal, Sudarshan. Clinical and echocardiographic predictors of mortality in acute pulmonary embolism. Cardiovascular Ultrasound. October 2016; 14(1) . http://hdl.handle.net/10342/8461. Accessed February 26, 2021.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback