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    Cutaneous melanoma: From pathogenesis to therapy (Review)

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    Author
    Leonardi, Giulia C.; Falzone, Luca; Salemi, Rossella; Zanghi, Antonino; Spandidos, Demetrios A.; Mccubrey, James A.
    Abstract
    In less than 10 years, melanoma treatment has been revolutionized with the approval of tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to have a significant impact on the prognosis of patients with melanoma. The early steps of this transformation have taken place in research laboratories. The mitogen-activated protein kinase (MAPK) pathway, phosphoinositol-3-kinase (PI3K) pathway promote the development of melanoma through numerous genomic alterations on different components of these pathways. Moreover, melanoma cells deeply interact with the tumor microenvironment and the immune system. This knowledge has led to the identification of novel therapeutic targets and treatment strategies. In this review, the epidemiological features of cutaneous melanoma along with the biological mechanisms involved in its development and progression are summarized. The current state-of-the-art of advanced stage melanoma treatment strategies and the currently available evidence of the use of predictive and prognostic biomarkers are also discussed.
    URI
    http://hdl.handle.net/10342/8464
    Date
    2018-02-27
    Citation:
    APA:
    Leonardi, Giulia C., & Falzone, Luca, & Salemi, Rossella, & Zanghi, Antonino, & Spandidos, Demetrios A., & Mccubrey, James A.. (February 2018). Cutaneous melanoma: From pathogenesis to therapy (Review). INTERNATIONAL JOURNAL OF ONCOLOGY, (1071-1080. Retrieved from http://hdl.handle.net/10342/8464

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Leonardi, Giulia C., and Falzone, Luca, and Salemi, Rossella, and Zanghi, Antonino, and Spandidos, Demetrios A., and Mccubrey, James A.. "Cutaneous melanoma: From pathogenesis to therapy (Review)". INTERNATIONAL JOURNAL OF ONCOLOGY. . (1071-1080.), February 2018. August 17, 2022. http://hdl.handle.net/10342/8464.
    Chicago:
    Leonardi, Giulia C. and Falzone, Luca and Salemi, Rossella and Zanghi, Antonino and Spandidos, Demetrios A. and Mccubrey, James A., "Cutaneous melanoma: From pathogenesis to therapy (Review)," INTERNATIONAL JOURNAL OF ONCOLOGY 52, no. (February 2018), http://hdl.handle.net/10342/8464 (accessed August 17, 2022).
    AMA:
    Leonardi, Giulia C., Falzone, Luca, Salemi, Rossella, Zanghi, Antonino, Spandidos, Demetrios A., Mccubrey, James A.. Cutaneous melanoma: From pathogenesis to therapy (Review). INTERNATIONAL JOURNAL OF ONCOLOGY. February 2018; 52() 1071-1080. http://hdl.handle.net/10342/8464. Accessed August 17, 2022.
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