Cutaneous melanoma: From pathogenesis to therapy (Review)
Author
Leonardi, Giulia C.; Falzone, Luca; Salemi, Rossella; Zanghi, Antonino; Spandidos, Demetrios A.; Mccubrey, James A.
Abstract
In less than 10 years, melanoma treatment has been
revolutionized with the approval of tyrosine kinase inhibitors
and immune checkpoint inhibitors, which have been shown
to have a significant impact on the prognosis of patients with
melanoma. The early steps of this transformation have taken
place in research laboratories. The mitogen-activated protein
kinase (MAPK) pathway, phosphoinositol-3-kinase (PI3K)
pathway promote the development of melanoma through
numerous genomic alterations on different components of these
pathways. Moreover, melanoma cells deeply interact with the
tumor microenvironment and the immune system. This knowledge has led to the identification of novel therapeutic targets and
treatment strategies. In this review, the epidemiological features
of cutaneous melanoma along with the biological mechanisms
involved in its development and progression are summarized.
The current state-of-the-art of advanced stage melanoma treatment strategies and the currently available evidence of the use of
predictive and prognostic biomarkers are also discussed.
Date
2018-02-27
Citation:
APA:
Leonardi, Giulia C., & Falzone, Luca, & Salemi, Rossella, & Zanghi, Antonino, & Spandidos, Demetrios A., & Mccubrey, James A.. (February 2018).
Cutaneous melanoma: From pathogenesis to therapy (Review).
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8464
MLA:
Leonardi, Giulia C., and Falzone, Luca, and Salemi, Rossella, and Zanghi, Antonino, and Spandidos, Demetrios A., and Mccubrey, James A..
"Cutaneous melanoma: From pathogenesis to therapy (Review)". .
. (),
February 2018.
September 30, 2023.
http://hdl.handle.net/10342/8464.
Chicago:
Leonardi, Giulia C. and Falzone, Luca and Salemi, Rossella and Zanghi, Antonino and Spandidos, Demetrios A. and Mccubrey, James A.,
"Cutaneous melanoma: From pathogenesis to therapy (Review)," , no.
(February 2018),
http://hdl.handle.net/10342/8464 (accessed
September 30, 2023).
AMA:
Leonardi, Giulia C., Falzone, Luca, Salemi, Rossella, Zanghi, Antonino, Spandidos, Demetrios A., Mccubrey, James A..
Cutaneous melanoma: From pathogenesis to therapy (Review). .
February 2018;
():
.
http://hdl.handle.net/10342/8464. Accessed
September 30, 2023.
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