• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    •   ScholarShip Home
    • Other Campus Research
    • Open Access
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer

    Thumbnail
    View/ Open
    oncotarget-07-72758.pdf (3.494Mb)

    Show full item record
    
    Author
    Falzone, Luca; Candido, Saverio; Salemi, Rossella; Basile, Maria S.; Scalisi, Aurora; McCubrey, James A.; Torino, Francesco; Signorelli, Salvatore S.; Montella, Maurizio; Libra, Massimo
    Abstract
    Bladder cancer is one of the leading cancer of the urinary tract. It is often diagnosed at advanced stage of the disease. To date, no specific and effective early detection biomarkers are available. Cancer development and progression are associated with the involvement of both epithelial-mesenchymal transition (EMT) and tumor microenvironment of which NGAL/MMP-9 complex represents the main player in bladder cancer. It is known that change in microRNAs (miRNAs) expression may result in gene modulation. Therefore, the identification of specific miRNAs associated with EMT pathway and NGAL/MMP-9 complex may be useful to detect the development of bladder cancer at early stages. On this ground, the expression levels of miRNAs in public available datasets of bladder cancer containing data of non-coding RNA profiling was evaluated. This analysis revealed a group of 16 miRNAs differentially expressed between bladder cancer patients and related healthy controls. By miRNA prediction tool (mirDIP), the relationship between the identified miRNAs and the EMT genes was established. Using the DIANA-mirPath (v.2) software, miRNAs, able to modulate the expression of NGAL and MMP-9 genes, were recognized. The results of this study provide evidence that the downregulated hsa-miR-145-5p and hsa-miR-214-3p may modulate the expression of both EMT and NGAL/MMP-9 pathways. Therefore, further validation analyses may confirm the usefulness of these selected miRNAs for predicting the development of bladder cancer at the early stage of the disease.
    URI
    http://hdl.handle.net/10342/8497
    Date
    2016-11-08
    Citation:
    APA:
    Falzone, Luca, & Candido, Saverio, & Salemi, Rossella, & Basile, Maria S., & Scalisi, Aurora, & McCubrey, James A., & Torino, Francesco, & Signorelli, Salvatore S., & Montella, Maurizio, & Libra, Massimo. (November 2016). Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer. Oncotarget, (7:45), p.72758–72766. Retrieved from http://hdl.handle.net/10342/8497

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Falzone, Luca, and Candido, Saverio, and Salemi, Rossella, and Basile, Maria S., and Scalisi, Aurora, and McCubrey, James A., and Torino, Francesco, and Signorelli, Salvatore S., and Montella, Maurizio, and Libra, Massimo. "Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer". Oncotarget. 7:45. (72758–72766.), November 2016. March 01, 2021. http://hdl.handle.net/10342/8497.
    Chicago:
    Falzone, Luca and Candido, Saverio and Salemi, Rossella and Basile, Maria S. and Scalisi, Aurora and McCubrey, James A. and Torino, Francesco and Signorelli, Salvatore S. and Montella, Maurizio and Libra, Massimo, "Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer," Oncotarget 7, no. 45 (November 2016), http://hdl.handle.net/10342/8497 (accessed March 01, 2021).
    AMA:
    Falzone, Luca, Candido, Saverio, Salemi, Rossella, Basile, Maria S., Scalisi, Aurora, McCubrey, James A., Torino, Francesco, Signorelli, Salvatore S., Montella, Maurizio, Libra, Massimo. Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer. Oncotarget. November 2016; 7(45) 72758–72766. http://hdl.handle.net/10342/8497. Accessed March 01, 2021.
    Collections
    • Open Access

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback