• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • ECU Main Campus
    • Honors College
    • View Item
    •   ScholarShip Home
    • ECU Main Campus
    • Honors College
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE

    Thumbnail
    View/ Open
    FREE-HONORSTHESIS-2021.pdf (309.6Kb)

    Show full item record
    Author
    Free, Katrina
    Abstract
    Acute High and Moderate Intensity Treadmill Exercise Increases Appetite and NPY/AgRP and TH Neuron Activity in Untrained Female Mice Background: Exercise is commonly prescribed as a means for weight loss, however, exercise programs frequently have mixed success rates. Recent studies have shown exercise intensities differentially modulate appetite and appetite-regulating neurons in the hypothalamus. Furthermore, these studies have primarily focused on the effects in male mice, and the effects in female mice are unknown. As a result, this study examines the effects of different acute treadmill exercise intensities on appetite regulation in female mice. Methods: 11 8-week old untrained female mice participated in a randomized-crossover trial of sedentary (sitting on top of running treadmill), low (10 m/min), moderate (14 m/min), and high (18 m/min) intensity acute treadmill exercise. The mice were fasted for 10 hours prior to each trial with 7 days between trials. Food intakes were measured at 1, 2, 3, 6, 12, 24, and 48 hours after exercise. An additional cohort of mice were perfused with PBS and formalin 3 hours post-exercise, and brains were extracted. Immunohistochemical detection for cFOS was performed to determine changes in NPY/AgRP, POMC, TH, and SIM1 neuron activity in response to exercise. Results: Compared to sedentary trials, cumulative 24-hour food intake was greater following moderate and high intensity exercise, predominantly due to increased food intake 6-12 hours post-exercise. These increases in food intake were associated with increases in activity of the orexigenic NPY/AgRP and TH neuron populations in the arcuate nucleus of the hypothalamus. Interestingly, no effects on appetite were observed in response to low intensity exercise. Conclusion: These results indicate that higher exercise intensities increase 24 hour food intake post-exercise in female mice, possibly explaining the low success rates of exercise-focused weight loss programs. Low intensity exercise may be a useful exercise regimen due to the absence of compensatory increases in appetite.
    URI
    http://hdl.handle.net/10342/9214
    Subject
     food intake; exercise intensity; hypothalamic neuron activity 
    Date
    2021-05-28
    Citation:
    APA:
    Free, Katrina. (May 2021). ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE (Honors Thesis, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/9214.)

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Free, Katrina. ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE. Honors Thesis. East Carolina University, May 2021. The Scholarship. http://hdl.handle.net/10342/9214. September 29, 2023.
    Chicago:
    Free, Katrina, “ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE” (Honors Thesis., East Carolina University, May 2021).
    AMA:
    Free, Katrina. ACUTE HIGH INTENSITY TREADMILL EXERCISE INCREASES APPETITE AND NPY/AgRP AND TH NEURON ACTIVITY IN UNTRAINED FEMALE MICE [Honors Thesis]. Greenville, NC: East Carolina University; May 2021.
    Collections
    • Honors College
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback