Browsing Interdisciplinary Biological Sciences by Title
Now showing items 5-14 of 14
-
The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response
(East Carolina University, 2010)Poxviruses are large double-stranded DNA viruses with a broad host range and worldwide distribution. The most infamous poxvirus is Variola virus, the causative agent of smallpox, which caused over 500 million deaths in ... -
Recruitment of Estuarine-Dependent Alosines to Roanoke River and Albemarle Sound, North Carolina
(East Carolina University, 2012)The deleterious effects of dams on alosine populations are widely documented in many rivers along the Atlantic coast. Alterations to the natural hydrologic regime can disrupt spawning, egg dispersal, and recruitment of ... -
Reproductive Toxicity of Crude oil-Dispersant Mixture in Caenorhabditis elegans
(East Carolina University, 2016-05-05)As crude oil remains a vital natural resource for the energy need of the world, environmental crude oil spills continue to be a health risk to human beings and ecological systems. During clean-up efforts, surfactant-like ... -
The role of peroxisome proliferator-activated receptor-gamma in surfactant catabolism in the alveolar macrophage
(East Carolina University, 2009)Pulmonary alveolar proteinosis (PAP) is a lung disease characterized by surfactant accumulation in the alveolar spaces and alveolar macrophages. Although PAP is rare, surfactant abnormalities occur in many lung diseases ... -
The serine protease from the venom of polistes dominulus contains allergenic epitopes
(East Carolina University, 2010)The protection introduced by immunotherapy to patients with allergies to paper wasps may be partial depending on the sensitizing species. Partial cross-reactivity between major paper wasp groups may be the reason for ... -
The Differential Roles of pH sensing G-Protein Coupled Receptors in Inflammation and Cancer
(East Carolina University, 2022-12-13)Intestinal inflammation is a burdening disease that may occur due to an aberrative immune response to certain drugs, infections, genetics, or unknown environmental factors. Inflammatory bowel disease (IBD) is of special ... -
The Functional Roles of pH-sensing G protein-coupled receptors in Intestinal Inflammation
(East Carolina University, 2018-12-06)The inflammatory microenvironment in inflammatory bowel disease (IBD) is complex, replete with microbial byproducts, complement, leukocytes, and resulting inflammatory cytokines. Parallel to these microenvironmental factors ... -
THE ROLE OF THE ALVEOLAR MACROPHAGE IN CARBON NANOTUBE ELICITED MURINE MODEL OF PULMONARY GRANULOMATOUS INFLAMMATION
(East Carolina University, 2018-11-29)Pulmonary sarcoidosis is a debilitating inflammatory condition characterized by the presence of granulomatous lesions throughout the lung. Granulomas are a physiological response to inhaled antigens or particulate matter ... -
Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
(East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...