Browsing Pharmacology and Toxicology by Issue Date
Now showing items 101-114 of 114
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The Endocannabinoid System Regulates Synaptogenesis in a Cortical Spheroid Model of Fetal Neurodevelopment
(East Carolina University, 2021-07-20)The endocannabinoid system plays a complex role in synaptogenesis and the subsequent development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 controls synaptic strength at both ... -
ROLE OF EPICARDIAL ADIPOSE TISSUE SECRETED INTERLEUKIN-34 IN FIBROBLAST TO MYOFIBROBLAST TRANSDIFFERENTIATION AND ATRIAL FIBROSIS
(East Carolina University, 2021-07-26)The adiposity of the heart has been proven to be significantly associated with cardiac dysfunction. Chronic low-grade inflammation of the adipose tissue and cardiac fibrosis are common complications in type 2 diabetes ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Kinin B1 Receptor Mediated Mechanisms in Hypertension
(East Carolina University, 2022-08-15)Hypertension continues to cause a burden on the global population as there are growing numbers of patients who present with treatment resistant hypertension. The etiology of hypertension is considered complex and multifactorial ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Kinin B1 Receptor Mediated Mechanisms in Hypertension
(East Carolina University, 2022-08-15)Hypertension continues to cause a burden on the global population as there are growing numbers of patients who present with treatment resistant hypertension. The etiology of hypertension is considered complex and multifactorial ... -
Molecular Mechanisms Underlying Cannabidiol-Improved Vocal Recovery Following Damage to a Songbird Vocal Pre-Motor Cortical-Like Region
(East Carolina University, 2023-04-27)The non-euphorigenic phytocannabinoid CBD has been found to be effective in treating childhood-onset epilepsies, conditions that are often associated with developmental delays, including vocal communication. Zebra finch ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ...