Browsing Pharmacology and Toxicology by Author "Brown, Jared"
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Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium
Bonner, James C.; Silva, Rona M.; Taylor, Alexia J.; Brown, Jared; Hilderbrand, Susana C.; Castranova, Vincent; Porter, Dale; Elder, Alison; Oberdörster, Günter; Harkema, Jack R.; Bramble, Lori A.; Kavanagh, Terrance J.; Botta, Dianne; Nel, Andre; Pinkerton, Kent E. (2013-05)Background: Engineered nanomaterials (ENMs) have potential benefits, but they also present safety concerns for human health. Interlaboratory studies in rodents using standardized protocols are needed to assess ENM ... -
Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33/ST2 axis
Wang, Xiaojia; Podila, Ramakrishna; Shannahan, Jonathan H.; Rao, Apparao M.; Brown, Jared (2013)Carbon-based nanomaterials (CBN), such as graphene nanosheets (GNS) and multiwalled carbon nanotubes (MWCNT), have been proposed for potential nanomedicine applications such as biomedical devices and carriers for drug ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
Katwa, Pranita (East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
Wang, Xiaojia; Katwa, Pranita; Podila, Ramakrishna; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Walters, Dianne M.; Wingard, Christopher J.; Brown, Jared (2011)Background Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental ...