Magneto Mechanical Actuation to Treat Brain Cancer

Abstract

Glioblastoma is the most aggressive and lethal form of brain cancer, remains highly resistant to conventional treatments due to its invasive nature and complex tumor microenvironment. In 2023, an estimated 2 million new cases of brain cancer were reported worldwide, with over 25,000 new cases of malignant brain tumors diagnosed in the United States alone. Current treatment modalities, such as ionizing radiation therapy and chemotherapy, are associated with significant limitations, including high costs (~$82,000 per treatment course) and severe side effects, such as cognitive decline and damage to surrounding healthy tissue. The urgent need for alternative therapeutic strategies has driven research into nanotechnology-based approaches that enhance drug efficacy while minimizing toxicity.