Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Loading...
Date
2016
Access
Authors
Lee, Seung-Hwan
Zabolotny, Janice
Huang, Hu
Lee, Hyon
Kim, Young-Bum
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. Scope of review: Here we review experimental and clinical work that has broadened the understanding of insulin's diverse functions in the central and peripheral nervous systems, including glucose and body weight homeostasis, memory and mood, with particular emphasis on intranasal insulin. Major conclusions: Implications for the treatment of obesity, type 2 diabetes, dementia, and mood disorders are discussed in the context of brain insulin action. Intranasal insulin may have potential in the treatment of central nervous system-related metabolic disorders. Keywords: Insulin, Intranasal insulin, Memory, Metabolism, Mood