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Breaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune Perspectives

dc.contributor.authorDietert, Rodney R.
dc.contributor.authorDeWitt, Jamie C.
dc.contributor.authorGermolec, Dori R.
dc.contributor.authorZelikoff, Judith T.
dc.date.accessioned2016-06-27T18:29:48Z
dc.date.available2016-06-27T18:29:48Z
dc.date.issued2010-08
dc.description.abstractDiseases rarely, if ever, occur in isolation. Instead, most represent part of a more complex web or “pattern” of conditions that are connected via underlying biological mechanisms and processes, emerge across a lifetime, and have been identified with the aid of large medical databases. Objective We have described how an understanding of patterns of disease may be used to develop new strategies for reducing the prevalence and risk of major immune-based illnesses and diseases influenced by environmental stimuli. Findings Examples of recently defined patterns of diseases that begin in childhood include not only metabolic syndrome, with its characteristics of inflammatory dysregulation, but also allergic, autoimmune, recurrent infection, and other inflammatory patterns of disease. The recent identification of major immune-based disease patterns beginning in childhood suggests that the immune system may play an even more important role in determining health status and health care needs across a lifetime than was previously understood. Conclusions Focusing on patterns of disease, as opposed to individual conditions, offers two important venues for environmental health risk reduction. First, prevention of developmental immunotoxicity and pediatric immune dysfunction can be used to act against multiple diseases. Second, pattern-based treatment of entryway diseases can be tailored with the aim of disrupting the entire disease pattern and reducing the risk of later-life illnesses connected to underlying immune dysfunction. Disease-pattern–based evaluation, prevention, and treatment will require a change from the current approach for both immune safety testing and pediatric disease management.en_US
dc.identifier.citationEnvironmental Health Perspectives; 118:8 p. 1091-1099en_US
dc.identifier.doi10.1289/ehp.1001971
dc.identifier.issn0091-6765
dc.identifier.pmidpmc2920092en_US
dc.identifier.urihttp://hdl.handle.net/10342/5765
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920092/en_US
dc.subjectasthmaen_US
dc.subjectdevelopmental immunotoxicityen_US
dc.subjecthealth risksen_US
dc.subjectimmune dysfunctionen_US
dc.subjectinflammationen_US
dc.subjectinterventionen_US
dc.subjectmetabolic syndromeen_US
dc.subjectpatterns of diseaseen_US
dc.subjectpreventionen_US
dc.subjectsafety testingen_US
dc.titleBreaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune Perspectivesen_US
dc.typeArticleen_US
ecu.journal.issue8en_US
ecu.journal.nameEnvironmental Health Perspectivesen_US
ecu.journal.pages1091-1099en_US
ecu.journal.volume118en_US

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