AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION

dc.access.option	Open Access
dc.contributor.advisor	Allen, William E.
dc.contributor.author	Shields, Agne A
dc.contributor.department	Chemistry
dc.date.accessioned	2023-02-28T15:29:45Z
dc.date.available	2023-02-28T15:29:45Z
dc.date.created	2024-05
dc.date.issued	2022-12-14
dc.date.submitted	May 2024
dc.date.updated	2023-02-27T16:25:43Z
dc.degree.department	Chemistry
dc.degree.discipline	Chemistry
dc.degree.grantor	East Carolina University
dc.degree.level	Undergraduate
dc.degree.name	BS
dc.description.abstract	Loss of a nucleic acid base from DNA can leave behind a reactive aldehyde group on ribose. To detect the presence of such “abasic sites,” ethyl-2-aminoazulene-1-carboxylate, a novel azulene-based analog of guanine/adenine, was synthesized. Valeraldehyde was chosen as a simple model for an abasic site. 1H NMR kinetics studies with ethyl-2-aminoazulene-1-carboxylate and valeraldehyde show that this is a slow reaction and suggest that it is zero-order with respect to valeraldehyde. This is consistent with a complex mechanism.
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/10342/12366
dc.publisher	East Carolina University
dc.subject	azulene
dc.subject	kinetics
dc.subject	DNA damage
dc.title	AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION
dc.type	Honors Thesis
dc.type.material	text

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