Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age

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dc.contributor.authorKuban, Karl C. K.en_US
dc.contributor.authorAllred, Elizabeth N.en_US
dc.contributor.authorO'Shea, T. Michaelen_US
dc.contributor.authorPaneth, Nigelen_US
dc.contributor.authorPagano, Marcelloen_US
dc.contributor.authorDammann, Olafen_US
dc.contributor.authorLeviton, Alanen_US
dc.contributor.authorPlessis, Adre Duen_US
dc.contributor.authorWestra, Sjirk J.en_US
dc.contributor.authorMiller, Cindy R.en_US
dc.contributor.authorBassan, Haimen_US
dc.contributor.authorKrishnamoorthy, Kalpathyen_US
dc.contributor.authorJunewick, Josephen_US
dc.contributor.authorOlomu, Nicholasen_US
dc.contributor.authorRomano, Elaineen_US
dc.contributor.authorSeibert, Joannaen_US
dc.contributor.authorEngelke, Stephen C.en_US
dc.contributor.authorKarna, Padmanien_US
dc.contributor.authorBatton, Danielen_US
dc.contributor.authorO'Connor, Sunila E.en_US
dc.contributor.authorKeller, Cecelia E.en_US
dc.date.accessioned2011-04-15T15:44:21Zen_US
dc.date.accessioned2011-05-17T00:38:33Z
dc.date.available2011-04-15T15:44:21Zen_US
dc.date.available2011-05-17T00:38:33Z
dc.date.issued2009-01en_US
dc.description.abstractOur prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. Originally published Journal of Child Neurology, Vol. 24, No. 1, Jan 2009en_US
dc.identifier.citationJournal of Child Neurology; 24:1 p. 63-72en_US
dc.identifier.doi10.1177/0883073808321048
dc.identifier.pmidPMC2814246en_US
dc.identifier.urihttp://hdl.handle.net/10342/3330en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://jcn.sagepub.com/content/24/1/63.longen_US
dc.rightsAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.en_US
dc.subjectCerebral palsyen_US
dc.subjectEstremely low gestational ageen_US
dc.subjectCranial ultrasounden_US
dc.titleCranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Ageen_US
dc.typeArticleen_US
ecu.journal.issue1
ecu.journal.nameJournal of Child Neurology
ecu.journal.pages63-72
ecu.journal.volume24

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