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Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration

dc.contributor.authorYamova, Liuboven_US
dc.contributor.authorAtochin, Dmitriyen_US
dc.contributor.authorGlazova, Margaritaen_US
dc.contributor.authorChernigovskaya, Elenaen_US
dc.contributor.authorHuang, Paulen_US
dc.date.accessioned2011-04-15T16:30:50Zen_US
dc.date.accessioned2011-05-17T00:56:27Z
dc.date.available2011-04-15T16:30:50Zen_US
dc.date.available2011-05-17T00:56:27Z
dc.date.issued2007-10-22en_US
dc.description.abstractWe used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic neurosecretory centers. nNOS gene deletion did not change the level of vasopressin mRNA in the supraoptic or paraventricular nuclei. In contrast, vasopressin immunoreactivity was lower in nNOS deficient mice than in wild-type animals. Dehydration increased vasopressin mRNA levels and decreased vasopressin immunoreactivity in both wild-type and nNOS knockout mice, but these responses were more marked in the nNOS knockout mice. Treatment with α-mpt, a pharmacologic inhibitor of catecholamine synthesis, resulted in increased vasopressin mRNA levels in wild-type mice and in reduced vasopressin immunoreactivity in both wild-type and nNOS knockout mice. From these results, we conclude: (1) neuronal nitric oxide suppresses vasopressin expression under basal conditions and during activation of the vasopressin-ergic system by dehydration; (2) catecholamines limit vasopressin expression; (3) nNOS is required for the effects of catecholamines on vasopressin expression. Originally published Neuroscience Letters, Vol. 426, No. 3, Oct 2007en_US
dc.identifier.citationNeuroscience Letters; 426:3 p. 160-165en_US
dc.identifier.pmidPMC2768346en_US
dc.identifier.urihttp://hdl.handle.net/10342/3335en_US
dc.language.isoen_USen_US
dc.publisherEast Carolina Universityen_US
dc.relation.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4PMT33H-1&_user=10&_coverDate=10%2F22%2F2007&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9e18d5db135272ce7caac7e589c68183&searchtype=aen_US
dc.subjectVasopressinen_US
dc.subjectNitric Oxideen_US
dc.subjectCatecholaminesen_US
dc.titleRole of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydrationen_US
dc.typeArticleen_US

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